Rosuvastatin and Glecaprevir/Pibrentasvir Interaction
Drug interaction information between Rosuvastatin and Glecaprevir/Pibrentasvir.
Rosuvastatin and Glecaprevir/Pibrentasvir have a documented major interaction in FDA labeling.
FDA drug labeling documents a major-severity interaction between Rosuvastatin and Glecaprevir/Pibrentasvir. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
These drugs can cause rosuvastatin levels to rise in your body, which may increase the risk of side effects.
FDA Label Information
Simeprevir Dasabuvir/ombitasvir/paritaprevir/ritonavir Elbasvir/grazoprevir Sofosbuvir/velpatasvir Glecaprevir/pibrentasvir Atazanavir/ritonavir Lopinavir/ritonavir Initiate with rosuvastatin 5 mg once daily, and do not exceed a dose of rosuvastatin 10 mg once daily.
Rosuvastatin Also Interacts With
- Sofosbuvir/Velpatasvir major
- Febuxostat major
- Cyclosporine moderate
- Ledipasvir/Sofosbuvir moderate
- Colchicine moderate
Glecaprevir/Pibrentasvir Also Interacts With
- Rifampin major
- Rosuvastatin/Ezetimibe major
- Cyclosporine moderate
- Darunavir moderate
- Estradiol moderate
Frequently Asked Questions
What SPL severity band is on file for Rosuvastatin + Glecaprevir/Pibrentasvir?
Compiled FDA labeling labels this pair major. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Glecaprevir/Pibrentasvir has 38 labeled pairs on file vs Rosuvastatin's 21. In the major band specifically: Rosuvastatin has 3 (also Sofosbuvir/Velpatasvir, Febuxostat); Glecaprevir/Pibrentasvir has 3 (also Rifampin, Rosuvastatin/Ezetimibe).
What mechanism field is on file for Rosuvastatin and Glecaprevir/Pibrentasvir?
These drugs can cause rosuvastatin levels to rise in your body, which may increase the risk of side effects.
Glecaprevir/Pibrentasvir's labeled portfolio outnumbers Rosuvastatin
SPL source-record counts only. This page's band is major · classes on file: Rosuvastatin (HMG-CoA Reductase Inhibitor (Statin)); Glecaprevir/Pibrentasvir (NS3/4A/NS5A Inhibitor (HCV)).
3 major · 8 moderate · 10 minor · 21 total
- Other major peers for Rosuvastatin
- Sofosbuvir/Velpatasvir
- Febuxostat
3 major · 9 moderate · 26 minor · 38 total
- Other major peers for Glecaprevir/Pibrentasvir
- Rifampin
- Rosuvastatin/Ezetimibe
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.