Progesterone and Ziprasidone Interaction
Drug interaction information between Progesterone and Ziprasidone.
Progesterone and Ziprasidone have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Progesterone and Ziprasidone. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Ziprasidone does not affect how the body absorbs, uses, or gets rid of progesterone. The hormone levels in your body remain stable when taking this medication.
FDA Label Information
7.6 Oral Contraceptives In vivo studies have revealed no effect of ziprasidone on the pharmacokinetics of estrogen or progesterone components.
Progesterone Also Interacts With
- Isotretinoin major
- Theophylline major
- Amoxicillin minor
- Amoxicillin/Clavulanate minor
- Medroxyprogesterone minor
Ziprasidone Also Interacts With
- Buspirone moderate
- Lithium moderate
- Tetrabenazine moderate
- Estradiol minor
- Propranolol minor
Frequently Asked Questions
What SPL severity band is on file for Progesterone + Ziprasidone?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Ziprasidone has 18 labeled pairs on file vs Progesterone's 7. In the minor band specifically: Progesterone has 5 (also Amoxicillin, Amoxicillin/Clavulanate, Medroxyprogesterone, Phenobarbital); Ziprasidone has 15 (also Estradiol, Propranolol, Lorazepam, Ketoconazole).
What mechanism field is on file for Progesterone and Ziprasidone?
Ziprasidone does not affect how the body absorbs, uses, or gets rid of progesterone. The hormone levels in your body remain stable when taking this medication.
Progesterone carries more major-labeled pairs than Ziprasidone
SPL source-record counts only. This page's band is minor · classes on file: Progesterone (Progestogen Hormone); Ziprasidone (Atypical Antipsychotic).
Progesterone has 2 major-labeled pairs vs Ziprasidone's 0. This page itself is in the minor band, not the major band.
2 major · 0 moderate · 5 minor · 7 total
- Other minor peers for Progesterone
- Amoxicillin
- Amoxicillin/Clavulanate
- Medroxyprogesterone
- Phenobarbital
0 major · 3 moderate · 15 minor · 18 total
- Other minor peers for Ziprasidone
- Estradiol
- Propranolol
- Lorazepam
- Ketoconazole
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.