Progesterone and Theophylline Interaction
Drug interaction information between Progesterone and Theophylline.
Progesterone and Theophylline have a documented major interaction in FDA labeling.
FDA drug labeling documents a major-severity interaction between Progesterone and Theophylline. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
It is not fully known how progesterone affects theophylline, but it may change how quickly your body clears the drug. This could lead to theophylline levels being higher or lower than expected.
FDA Label Information
The effect of progesterone on theophylline clearance is unknown. albuterol, systemic and inhaled mebendazole amoxicillin medroxyprogesterone ampicillin, with or without sulbactam methylprednisolone atenolol metronidazole azithromycin metoprolol caffeine, dietary ingestion nadolol cefaclor nifedipine co-trimoxazole (trimethoprim and sulfamethoxazole) nizatidine diltiazem norfloxacin dirithromycin ofloxacin enflurane omeprazole famotidine prednisone, prednisolone felodipine ranitidine finasteride rifabutin hydrocortisone roxithromycin isoflurane Sorbitol (purgative doses do not inhibit...
Progesterone Also Interacts With
- Isotretinoin major
- Amoxicillin minor
- Amoxicillin/Clavulanate minor
- Medroxyprogesterone minor
- Phenobarbital minor
Theophylline Also Interacts With
- Metoprolol major
- Albuterol major
- Omeprazole major
- Amoxicillin major
- Famotidine major
Frequently Asked Questions
What SPL severity band is on file for Progesterone + Theophylline?
Compiled FDA labeling labels this pair major. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Theophylline has 86 labeled pairs on file vs Progesterone's 7. In the major band specifically: Progesterone has 2 (also Isotretinoin); Theophylline has 27 (also Metoprolol, Albuterol, Omeprazole, Amoxicillin).
What mechanism field is on file for Progesterone and Theophylline?
It is not fully known how progesterone affects theophylline, but it may change how quickly your body clears the drug. This could lead to theophylline levels being higher or lower than expected.
Theophylline carries more major-labeled pairs than Progesterone
SPL source-record counts only. This page's band is major · classes on file: Progesterone (Progestogen Hormone); Theophylline (Methylxanthine Bronchodilator).
Theophylline has 27 major-labeled pairs vs Progesterone's 2.
2 major · 0 moderate · 5 minor · 7 total
- Other major peers for Progesterone
- Isotretinoin
27 major · 5 moderate · 54 minor · 86 total
- Other major peers for Theophylline
- Metoprolol
- Albuterol
- Omeprazole
- Amoxicillin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.