Progesterone and Amoxicillin/Clavulanate Interaction
Drug interaction information between Progesterone and Amoxicillin/Clavulanate.
Progesterone and Amoxicillin/Clavulanate have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Progesterone and Amoxicillin/Clavulanate. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
This antibiotic can change the bacteria in your gut, which makes it harder for your body to absorb the hormones in birth control pills.
FDA Label Information
7.4 Oral Contraceptives AUGMENTIN may affect intestinal flora, leading to lower estrogen reabsorption and reduced efficacy of combined oral estrogen/progesterone contraceptives.
Progesterone Also Interacts With
- Isotretinoin major
- Theophylline major
- Amoxicillin minor
- Medroxyprogesterone minor
- Phenobarbital minor
Amoxicillin/Clavulanate Also Interacts With
- Allopurinol moderate
- Probenecid moderate
- Amoxicillin minor
- Estradiol minor
Frequently Asked Questions
What SPL severity band is on file for Progesterone + Amoxicillin/Clavulanate?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Progesterone has 7 labeled pairs on file vs Amoxicillin/Clavulanate's 5. In the minor band specifically: Progesterone has 5 (also Amoxicillin, Medroxyprogesterone, Phenobarbital, Ziprasidone); Amoxicillin/Clavulanate has 3 (also Amoxicillin, Estradiol).
What mechanism field is on file for Progesterone and Amoxicillin/Clavulanate?
This antibiotic can change the bacteria in your gut, which makes it harder for your body to absorb the hormones in birth control pills.
Progesterone carries more major-labeled pairs than Amoxicillin/Clavulanate
SPL source-record counts only. This page's band is minor · classes on file: Progesterone (Progestogen Hormone); Amoxicillin/Clavulanate (Penicillin / Beta-Lactamase Inhibitor Combination).
Progesterone has 2 major-labeled pairs vs Amoxicillin/Clavulanate's 0. This page itself is in the minor band, not the major band.
2 major · 0 moderate · 5 minor · 7 total
- Other minor peers for Progesterone
- Amoxicillin
- Medroxyprogesterone
- Phenobarbital
- Ziprasidone
0 major · 2 moderate · 3 minor · 5 total
- Other minor peers for Amoxicillin/Clavulanate
- Amoxicillin
- Estradiol
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.