What the FDA labels say about taking them together
Amoxicillin/clavulanate and progesterone
Amoxicillin/clavulanate's FDA label of May 1, 2025 names progesterone in its drug interactions section; the progesterone labels PlainMeds reads (3) do not name amoxicillin/clavulanate. The amoxicillin/clavulanate label: “Oral Contraceptives AUGMENTIN ES-600 may affect intestinal flora, leading to lower estrogen reabsorption and reduced efficacy of combined oral estrogen/progesterone contraceptives.”
Check it at the source: the amoxicillin/clavulanate FDA label on DailyMed (effective May 1, 2025, Sandoz Inc); the progesterone FDA label on DailyMed (effective July 23, 2026, Acertis Pharmaceuticals, LLC).
What does the amoxicillin/clavulanate label say about progesterone?
Amoxicillin/clavulanate label, drug interactionsAmoxicillin and clavulanate potassium may affect intestinal flora, leading to lower estrogen reabsorption and reduced efficacy of combined oral estrogen/progesterone contraceptives.
Source: FDA drug label (Amoxicillin And Clavulanate Potassium, NDA050785), USAntibiotics, LLC, effective July 7, 2026 (SPL set 45c60b69-1b65-01ed-e063-6294a90a57be), via openFDA
Source: FDA drug label (Augmentin Es-600, NDA050755), USAntibiotics, LLC, effective July 7, 2026 (SPL set 59979859-8c9b-4173-a5e3-2e6312fd9d79), via openFDA
Source: FDA drug label (Amoxicillin and Clavulanate Potassium), Sandoz Inc, effective May 1, 2025 (SPL set 7cba82f0-9886-46e9-8dbd-43a448aade29), via openFDA; the full label on DailyMed
What does the progesterone label say about amoxicillin/clavulanate?
Progesterone's label (effective July 23, 2026) and its 2 other brand-application labels do not name amoxicillin/clavulanate in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Prometrium), Acertis Pharmaceuticals, LLC, effective July 23, 2026 (SPL set 1cf237ff-c4f8-4faa-a7aa-77599c856889), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
These are the ingredient's own label sentences, repeated in a combination product's or a biosimilar's label. The ingredient pair sets them out with both labels side by side.
Both medicines on the record
| Amoxicillin/clavulanate | Progesterone | |
|---|---|---|
| Labeled for | Urinary tract infections, Bacterial infections | n/a |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.0693 per mL 600-42.9 mg/5 mL sus | $0.229 per capsule 100 mg capsule |
| Shortage now | No current entry | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once