Progesterone and Medroxyprogesterone Interaction
Drug interaction information between Progesterone and Medroxyprogesterone.
Progesterone and Medroxyprogesterone have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Progesterone and Medroxyprogesterone. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Medroxyprogesterone can reduce the levels of progesterone measured in your body.
FDA Label Information
Counsel patients to use a back-up method or alternative method of contraception when enzyme inducers are used with medroxyprogesterone acetate injectable suspension. The following laboratory tests may be affected by progestins including medroxyprogesterone acetate injectable suspension: (a) Plasma and urinary steroid levels are decreased (e.g., progesterone, estradiol, pregnanediol, testosterone, cortisol). (g) The effects of medroxyprogesterone acetate on lipid metabolism are inconsistent.
Progesterone Also Interacts With
- Isotretinoin major
- Theophylline major
- Amoxicillin minor
- Amoxicillin/Clavulanate minor
- Phenobarbital minor
Medroxyprogesterone Also Interacts With
- Theophylline major
- Estradiol minor
- Topiramate minor
- Testosterone minor
- Carbamazepine minor
Frequently Asked Questions
What SPL severity band is on file for Progesterone + Medroxyprogesterone?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Medroxyprogesterone has 11 labeled pairs on file vs Progesterone's 7. In the minor band specifically: Progesterone has 5 (also Amoxicillin, Amoxicillin/Clavulanate, Phenobarbital, Ziprasidone); Medroxyprogesterone has 10 (also Estradiol, Topiramate, Testosterone, Carbamazepine).
What mechanism field is on file for Progesterone and Medroxyprogesterone?
Medroxyprogesterone can reduce the levels of progesterone measured in your body.
Progesterone carries more major-labeled pairs than Medroxyprogesterone
SPL source-record counts only. This page's band is minor · classes on file: Progesterone (Progestogen Hormone); Medroxyprogesterone (Progestogen).
Progesterone has 2 major-labeled pairs vs Medroxyprogesterone's 1. This page itself is in the minor band, not the major band.
2 major · 0 moderate · 5 minor · 7 total
- Other minor peers for Progesterone
- Amoxicillin
- Amoxicillin/Clavulanate
- Phenobarbital
- Ziprasidone
1 major · 0 moderate · 10 minor · 11 total
- Other minor peers for Medroxyprogesterone
- Estradiol
- Topiramate
- Testosterone
- Carbamazepine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.