Progesterone and Medroxyprogesterone Interaction
Drug interaction information between Progesterone and Medroxyprogesterone.
Progesterone and Medroxyprogesterone have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Progesterone and Medroxyprogesterone. Major interactions are generally avoided, moderate ones may need monitoring or a dose adjustment, and minor ones are usually low-risk. This page shows the documented mechanism and guidance. Label-documented interactions are not a complete safety review, so always confirm your own medications with a pharmacist or doctor. Educational information, not medical advice.
How They Interact
Medroxyprogesterone can reduce the levels of progesterone measured in your body.
What To Do
Your doctor should be aware of this interaction when testing your hormone levels.
FDA Label Information
Counsel patients to use a back-up method or alternative method of contraception when enzyme inducers are used with medroxyprogesterone acetate injectable suspension. The following laboratory tests may be affected by progestins including medroxyprogesterone acetate injectable suspension: (a) Plasma and urinary steroid levels are decreased (e.g., progesterone, estradiol, pregnanediol, testosterone, cortisol). (g) The effects of medroxyprogesterone acetate on lipid metabolism are inconsistent.
Progesterone Also Interacts With
- Isotretinoin major
- Theophylline major
- Amoxicillin minor
- Amoxicillin/Clavulanate minor
- Phenobarbital minor
Medroxyprogesterone Also Interacts With
- Theophylline major
- Estradiol minor
- Topiramate minor
- Testosterone minor
- Carbamazepine minor
Frequently Asked Questions
Can I take Progesterone and Medroxyprogesterone together?
This is a minor interaction. Your doctor should be aware of this interaction when testing your hormone levels.
How serious is the interaction between Progesterone and Medroxyprogesterone?
This interaction is classified as "minor" severity by the FDA. Minor interactions are unlikely to cause significant problems but should still be mentioned to your healthcare provider.
Why do Progesterone and Medroxyprogesterone interact?
Medroxyprogesterone can reduce the levels of progesterone measured in your body.
Understanding the Progesterone and Medroxyprogesterone Interaction
FDA-approved prescribing information for these two drugs flags their combination as a minor-severity interaction. Progesterone belongs to the Progestogen Hormone class and Medroxyprogesterone belongs to the Progestogen class - two categories that can collide when co-prescribed. The mechanism described in FDA labeling is: Medroxyprogesterone can reduce the levels of progesterone measured in your body. Severity tiers matter: major flags generally advise avoidance, moderate flags often require monitoring or dose adjustment, and minor flags may only call for awareness.
Context around a specific patient determines real-world impact. Progesterone has 7 total documented interactions on file in this dataset, and Medroxyprogesterone has 11. Each additional medication compounds the interaction surface, which is why pharmacists run full-profile checks rather than evaluating one pair at a time. FDA-derived guidance for this pair is: Your doctor should be aware of this interaction when testing your hormone levels. Timing of doses, renal and hepatic function, age, and other concurrent prescriptions all shape whether a labeled interaction matters clinically.
An interaction flag is not a verdict. A large share of labeled interactions are managed routinely in clinical practice, the fix may be as simple as spacing doses or adding a monitoring test. Others require the prescriber to choose a different medication entirely. This page surfaces FDA-sourced labeling and openFDA data for educational purposes only; it is not medical advice and cannot account for your full clinical picture. Never start, stop, or adjust either Progesterone or Medroxyprogesterone based on a web page, speak with your prescriber or pharmacist before making any change.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. Always consult your healthcare provider about drug interactions.
Read our methodology - how this data is sourced, computed, and verified.