Glecaprevir/Pibrentasvir and Atorvastatin Interaction
Drug interaction information between Glecaprevir/Pibrentasvir and Atorvastatin.
Glecaprevir/Pibrentasvir and Atorvastatin have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Glecaprevir/Pibrentasvir and Atorvastatin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
This combination can cause the amount of atorvastatin in your blood to increase.
FDA Label Information
HMG-CoA Reductase Inhibitors: Atorvastatin Lovastatin Simvastatin ↑ atorvastatin ↑ lovastatin ↑ simvastatin Coadministration may increase the concentration of atorvastatin, lovastatin, and simvastatin.
Glecaprevir/Pibrentasvir Also Interacts With
- Rifampin major
- Rosuvastatin major
- Rosuvastatin/Ezetimibe major
- Cyclosporine moderate
- Darunavir moderate
Atorvastatin Also Interacts With
- Clarithromycin major
- Darunavir major
- Itraconazole major
- Cyclosporine moderate
- Colchicine moderate
Frequently Asked Questions
What SPL severity band is on file for Glecaprevir/Pibrentasvir + Atorvastatin?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Glecaprevir/Pibrentasvir has 38 labeled pairs on file vs Atorvastatin's 36. In the minor band specifically: Glecaprevir/Pibrentasvir has 26 (also Amlodipine, Losartan, Omeprazole, Simvastatin); Atorvastatin has 25 (also Estradiol, Norethindrone, Ketoconazole, Erythromycin).
What mechanism field is on file for Glecaprevir/Pibrentasvir and Atorvastatin?
This combination can cause the amount of atorvastatin in your blood to increase.
Glecaprevir/Pibrentasvir's labeled portfolio outnumbers Atorvastatin
SPL source-record counts only. This page's band is minor · classes on file: Glecaprevir/Pibrentasvir (NS3/4A/NS5A Inhibitor (HCV)); Atorvastatin (HMG-CoA Reductase Inhibitor (Statin)).
3 major · 9 moderate · 26 minor · 38 total
- Other minor peers for Glecaprevir/Pibrentasvir
- Amlodipine
- Losartan
- Omeprazole
- Simvastatin
3 major · 8 moderate · 25 minor · 36 total
- Other minor peers for Atorvastatin
- Estradiol
- Norethindrone
- Ketoconazole
- Erythromycin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.