Glecaprevir/Pibrentasvir and Cyclosporine Interaction
Drug interaction information between Glecaprevir/Pibrentasvir and Cyclosporine.
Glecaprevir/Pibrentasvir and Cyclosporine have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Glecaprevir/Pibrentasvir and Cyclosporine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Cyclosporine causes the levels of glecaprevir and pibrentasvir to increase in your body. This happens because cyclosporine interferes with how the body processes these medications.
FDA Label Information
Immunosuppressants: Cyclosporine ↑ glecaprevir ↑ pibrentasvir MAVYRET is not recommended for use in patients requiring stable cyclosporine doses > 100 mg per day.
Glecaprevir/Pibrentasvir Also Interacts With
- Rifampin major
- Rosuvastatin major
- Rosuvastatin/Ezetimibe major
- Darunavir moderate
- Estradiol moderate
Cyclosporine Also Interacts With
- Clarithromycin major
- Ezetimibe major
- Ezetimibe/Simvastatin major
- Pitavastatin major
- Simvastatin major
Frequently Asked Questions
What SPL severity band is on file for Glecaprevir/Pibrentasvir + Cyclosporine?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Cyclosporine has 89 labeled pairs on file vs Glecaprevir/Pibrentasvir's 38. In the moderate band specifically: Glecaprevir/Pibrentasvir has 9 (also Darunavir, Estradiol, Ethinyl Estradiol, Ethinyl Estradiol); Cyclosporine has 24 (also Aliskiren, Allopurinol, Amiloride, Amlodipine/Valsartan).
What mechanism field is on file for Glecaprevir/Pibrentasvir and Cyclosporine?
Cyclosporine causes the levels of glecaprevir and pibrentasvir to increase in your body. This happens because cyclosporine interferes with how the body processes these medications.
Cyclosporine carries more major-labeled pairs than Glecaprevir/Pibrentasvir
SPL source-record counts only. This page's band is moderate · classes on file: Glecaprevir/Pibrentasvir (NS3/4A/NS5A Inhibitor (HCV)); Cyclosporine (Calcineurin Inhibitor (Immunosuppressant)).
Cyclosporine has 5 major-labeled pairs vs Glecaprevir/Pibrentasvir's 3. This page itself is in the moderate band, not the major band.
3 major · 9 moderate · 26 minor · 38 total
- Other moderate peers for Glecaprevir/Pibrentasvir
- Darunavir
- Estradiol
- Ethinyl Estradiol
- Ethinyl Estradiol
5 major · 24 moderate · 60 minor · 89 total
- Other moderate peers for Cyclosporine
- Aliskiren
- Allopurinol
- Amiloride
- Amlodipine/Valsartan
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.