What the FDA labels say about taking them together
Cyclosporine and glecaprevir/pibrentasvir
Glecaprevir/pibrentasvir's FDA label of June 25, 2025 names cyclosporine in its drug interactions section; the cyclosporine labels PlainMeds reads (4) do not name glecaprevir/pibrentasvir. The glecaprevir/pibrentasvir label: “MAVYRET is not recommended for use in patients requiring stable cyclosporine doses > 100 mg per day.”
Check it at the source: the cyclosporine FDA label on DailyMed (effective August 10, 2026, Novartis Pharmaceuticals Corporation); the glecaprevir/pibrentasvir FDA label on DailyMed (effective June 25, 2025, AbbVie Inc.).
What does the cyclosporine label say about glecaprevir/pibrentasvir?
Cyclosporine's label (effective August 10, 2026) and its 3 other brand-application labels do not name glecaprevir/pibrentasvir in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Neoral), Novartis Pharmaceuticals Corporation, effective August 10, 2026 (SPL set 94461af3-11f1-4670-95d4-2965b9538ae3), via openFDA; the full label on DailyMed
What does the glecaprevir/pibrentasvir label say about cyclosporine?
Glecaprevir/pibrentasvir label, drug interactionsConcomitant Drug Class/Drug Name: Cyclosporine; Effect on Concentration: ↑ glecaprevir ↑ pibrentasvir; Clinical Comments: MAVYRET is not recommended for use in patients requiring stable cyclosporine doses > 100 mg per day.
Source: FDA drug label (Mavyret), AbbVie Inc., effective June 25, 2025 (SPL set 7bf99777-0401-9095-8645-16c6e907fcc0), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Cyclosporine | Glecaprevir/pibrentasvir | |
|---|---|---|
| Labeled for | Organ transplant rejection, Rheumatoid arthritis | Hepatitis C |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $1.04 per unit 0.05% eye emulsion | $152.98 per tablet 100-40 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once