Glecaprevir/Pibrentasvir and Darunavir Interaction
Drug interaction information between Glecaprevir/Pibrentasvir and Darunavir.
Glecaprevir/Pibrentasvir and Darunavir have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Glecaprevir/Pibrentasvir and Darunavir. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Darunavir increases the amount of glecaprevir and pibrentasvir that stays in your body. This can make the hepatitis C medication more likely to cause side effects.
FDA Label Information
glecaprevir/pibrentasvir ↑ glecaprevir ↑ pibrentasvir Co-administration of darunavir/ritonavir with glecaprevir/pibrentasvir is not recommended.
Glecaprevir/Pibrentasvir Also Interacts With
- Rifampin major
- Rosuvastatin major
- Rosuvastatin/Ezetimibe major
- Cyclosporine moderate
- Estradiol moderate
Darunavir Also Interacts With
- Lovastatin major
- Sildenafil major
- Lurasidone major
- Pimozide major
- Midazolam major
Frequently Asked Questions
What SPL severity band is on file for Glecaprevir/Pibrentasvir + Darunavir?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Darunavir has 101 labeled pairs on file vs Glecaprevir/Pibrentasvir's 38. In the moderate band specifically: Glecaprevir/Pibrentasvir has 9 (also Cyclosporine, Estradiol, Ethinyl Estradiol, Ethinyl Estradiol); Darunavir has 16 (also Omeprazole, Fluticasone, Apixaban, Clopidogrel).
What mechanism field is on file for Glecaprevir/Pibrentasvir and Darunavir?
Darunavir increases the amount of glecaprevir and pibrentasvir that stays in your body. This can make the hepatitis C medication more likely to cause side effects.
Darunavir carries more major-labeled pairs than Glecaprevir/Pibrentasvir
SPL source-record counts only. This page's band is moderate · classes on file: Glecaprevir/Pibrentasvir (NS3/4A/NS5A Inhibitor (HCV)); Darunavir (HIV Protease Inhibitor).
Darunavir has 15 major-labeled pairs vs Glecaprevir/Pibrentasvir's 3. This page itself is in the moderate band, not the major band.
3 major · 9 moderate · 26 minor · 38 total
- Other moderate peers for Glecaprevir/Pibrentasvir
- Cyclosporine
- Estradiol
- Ethinyl Estradiol
- Ethinyl Estradiol
15 major · 16 moderate · 70 minor · 101 total
- Other moderate peers for Darunavir
- Omeprazole
- Fluticasone
- Apixaban
- Clopidogrel
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.