Glecaprevir/Pibrentasvir and Amlodipine Interaction
Drug interaction information between Glecaprevir/Pibrentasvir and Amlodipine.
Glecaprevir/Pibrentasvir and Amlodipine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Glecaprevir/Pibrentasvir and Amlodipine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
These two drugs do not significantly change how the other drug works or stays in your body.
FDA Label Information
7.5 Drugs with No Observed Clinically Significant Interactions with MAVYRET No dose adjustment is required when MAVYRET is coadministered with the following medications: abacavir, amlodipine, caffeine, dextromethorphan, dolutegravir, elvitegravir/ cobicistat, emtricitabine, ethinyl estradiol of 20 mcg or less, felodipine, lamivudine, lamotrigine, losartan, midazolam, norethindrone or other progestin-only contraceptives, omeprazole, raltegravir, rilpivirine, sofosbuvir, tacrolimus, tenofovir alafenamide, tenofovir disoproxil fumarate, tolbutamide, and valsartan.
Glecaprevir/Pibrentasvir Also Interacts With
- Rifampin major
- Rosuvastatin major
- Rosuvastatin/Ezetimibe major
- Cyclosporine moderate
- Darunavir moderate
Amlodipine Also Interacts With
- Simvastatin major
- Amlodipine/Benazepril major
- Ezetimibe major
- Ezetimibe/Simvastatin major
- Nirmatrelvir/Ritonavir moderate
Frequently Asked Questions
What SPL severity band is on file for Glecaprevir/Pibrentasvir + Amlodipine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Glecaprevir/Pibrentasvir has 38 labeled pairs on file vs Amlodipine's 15. In the minor band specifically: Glecaprevir/Pibrentasvir has 26 (also Atorvastatin, Losartan, Omeprazole, Simvastatin); Amlodipine has 10 (also Sildenafil, Cyclosporine, Amlodipine/Valsartan, Clarithromycin).
What mechanism field is on file for Glecaprevir/Pibrentasvir and Amlodipine?
These two drugs do not significantly change how the other drug works or stays in your body.
Amlodipine carries more major-labeled pairs than Glecaprevir/Pibrentasvir
SPL source-record counts only. This page's band is minor · classes on file: Glecaprevir/Pibrentasvir (NS3/4A/NS5A Inhibitor (HCV)); Amlodipine (Calcium Channel Blocker).
Amlodipine has 4 major-labeled pairs vs Glecaprevir/Pibrentasvir's 3. This page itself is in the minor band, not the major band.
3 major · 9 moderate · 26 minor · 38 total
- Other minor peers for Glecaprevir/Pibrentasvir
- Atorvastatin
- Losartan
- Omeprazole
- Simvastatin
4 major · 1 moderate · 10 minor · 15 total
- Other minor peers for Amlodipine
- Sildenafil
- Cyclosporine
- Amlodipine/Valsartan
- Clarithromycin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.