Posaconazole and Lovastatin Interaction
Drug interaction information between Posaconazole and Lovastatin.
Posaconazole and Lovastatin have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Posaconazole and Lovastatin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Posaconazole stops the body from removing lovastatin properly, which can cause the drug to reach dangerous levels. This buildup increases the risk of a serious muscle-wasting condition.
FDA Label Information
Strong inhibitors of CYP3A4 (e.g., itraconazole, ketoconazole, posaconazole, voriconazole, clarithromycin, telithromycin, HIV protease inhibitors, boceprevir, telaprevir, nefazodone, erythromycin, and cobicistat-containing products), and grapefruit juice increase the risk of myopathy by reducing the elimination of lovastatin (see CONTRAINDICATIONS , WARNINGS , Myopathy/Rhabdomyolysis , and CLINICAL PHARMACOLOGY , Pharmacokinetics ).
Posaconazole Also Interacts With
- Esomeprazole major
- Digoxin major
- Cimetidine major
- Metoclopramide major
- Phenytoin major
Lovastatin Also Interacts With
- Darunavir major
- Nirmatrelvir/Ritonavir major
- Spironolactone moderate
- Ketoconazole moderate
- Verapamil moderate
Frequently Asked Questions
What SPL severity band is on file for Posaconazole + Lovastatin?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Lovastatin has 30 labeled pairs on file vs Posaconazole's 27. In the moderate band specifically: Posaconazole has 5 (also Efavirenz, Suvorexant, Tacrolimus Topical, Vorapaxar); Lovastatin has 17 (also Spironolactone, Ketoconazole, Verapamil, Cyclosporine).
What mechanism field is on file for Posaconazole and Lovastatin?
Posaconazole stops the body from removing lovastatin properly, which can cause the drug to reach dangerous levels. This buildup increases the risk of a serious muscle-wasting condition.
Posaconazole carries more major-labeled pairs than Lovastatin
SPL source-record counts only. This page's band is moderate · classes on file: Posaconazole (Azole Antifungal); Lovastatin (HMG-CoA Reductase Inhibitor (Statin)).
Posaconazole has 5 major-labeled pairs vs Lovastatin's 2. This page itself is in the moderate band, not the major band.
5 major · 5 moderate · 17 minor · 27 total
- Other moderate peers for Posaconazole
- Efavirenz
- Suvorexant
- Tacrolimus Topical
- Vorapaxar
2 major · 17 moderate · 11 minor · 30 total
- Other moderate peers for Lovastatin
- Spironolactone
- Ketoconazole
- Verapamil
- Cyclosporine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.