Posaconazole and Tacrolimus Topical Interaction
Drug interaction information between Posaconazole and Tacrolimus Topical.
Posaconazole and Tacrolimus Topical have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Posaconazole and Tacrolimus Topical. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Posaconazole stops your body from breaking down tacrolimus normally, which can cause the medicine to reach toxic levels in your blood. High levels of tacrolimus can lead to serious health issues like kidney or nerve problems.
FDA Label Information
Strong CYP3A Inhibitors : Protease inhibitors (e.g., nelfinavir, telaprevir, boceprevir, ritonavir), azole antifungals (e.g., voriconazole, posaconazole, itraconazole, ketoconazole), antibiotics (e.g., clarithromycin, troleandomycin, chloramphenicol), nefazodone, letermovir, Schisandra sphenanthera extracts May increase tacrolimus whole blood trough concentrations and increase the risk of serious adverse reactions (e.g., neurotoxicity, QT prolongation). Reduce tacrolimus extended-release capsules dose (for voriconazole and posaconazole, give one-third of the original dose) and adjust dose...
Posaconazole Also Interacts With
- Esomeprazole major
- Digoxin major
- Cimetidine major
- Metoclopramide major
- Phenytoin major
Tacrolimus Topical Also Interacts With
- Omeprazole moderate
- Estradiol moderate
- Diltiazem moderate
- Nifedipine moderate
- Ketoconazole moderate
Frequently Asked Questions
What SPL severity band is on file for Posaconazole + Tacrolimus Topical?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Posaconazole has 27 labeled pairs on file vs Tacrolimus Topical's 25. In the moderate band specifically: Posaconazole has 5 (also Efavirenz, Lovastatin, Suvorexant, Vorapaxar); Tacrolimus Topical has 19 (also Omeprazole, Estradiol, Diltiazem, Nifedipine).
What mechanism field is on file for Posaconazole and Tacrolimus Topical?
Posaconazole stops your body from breaking down tacrolimus normally, which can cause the medicine to reach toxic levels in your blood. High levels of tacrolimus can lead to serious health issues like kidney or nerve problems.
Posaconazole carries more major-labeled pairs than Tacrolimus Topical
SPL source-record counts only. This page's band is moderate · classes on file: Posaconazole (Azole Antifungal); Tacrolimus Topical (Calcineurin Inhibitor (Topical)).
Posaconazole has 5 major-labeled pairs vs Tacrolimus Topical's 0. This page itself is in the moderate band, not the major band.
5 major · 5 moderate · 17 minor · 27 total
- Other moderate peers for Posaconazole
- Efavirenz
- Lovastatin
- Suvorexant
- Vorapaxar
0 major · 19 moderate · 6 minor · 25 total
- Other moderate peers for Tacrolimus Topical
- Omeprazole
- Estradiol
- Diltiazem
- Nifedipine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.