Venlafaxine and Aspirin Interaction
Drug interaction information between Venlafaxine and Aspirin.
Venlafaxine and Aspirin have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Venlafaxine and Aspirin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Both drugs interfere with how blood cells called platelets work, which increases the risk of serious bleeding in the stomach or other areas.
FDA Label Information
Drugs that Interfere with Hemostasis (e.g., NSAIDs, Aspirin, and Warfarin) Serotonin release by platelets plays an important role in hemostasis. Epidemiological studies of the case-control and cohort design that have demonstrated an association between use of psychotropic drugs that interfere with serotonin reuptake and the occurrence of upper gastrointestinal bleeding have also shown that concurrent use of an NSAID or aspirin may potentiate this risk of bleeding.
Venlafaxine Also Interacts With
- Phenelzine moderate
- Metoprolol minor
- Fluoxetine minor
- Alprazolam minor
- Warfarin minor
Aspirin Also Interacts With
- Atenolol major
- Fluoxetine major
- Ibandronate major
- Alendronate moderate
- Apixaban moderate
Frequently Asked Questions
What SPL severity band is on file for Venlafaxine + Aspirin?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Aspirin has 47 labeled pairs on file vs Venlafaxine's 22. In the moderate band specifically: Venlafaxine has 2 (also Phenelzine); Aspirin has 12 (also Alendronate, Apixaban, Desvenlafaxine, Dexamethasone).
What mechanism field is on file for Venlafaxine and Aspirin?
Both drugs interfere with how blood cells called platelets work, which increases the risk of serious bleeding in the stomach or other areas.
Aspirin carries more major-labeled pairs than Venlafaxine
SPL source-record counts only. This page's band is moderate · classes on file: Venlafaxine (Serotonin-Norepinephrine Reuptake Inhibitor (SNRI)); Aspirin (Antiplatelet / NSAID).
Aspirin has 3 major-labeled pairs vs Venlafaxine's 0. This page itself is in the moderate band, not the major band.
0 major · 2 moderate · 20 minor · 22 total
- Other moderate peers for Venlafaxine
- Phenelzine
3 major · 12 moderate · 32 minor · 47 total
- Other moderate peers for Aspirin
- Alendronate
- Apixaban
- Desvenlafaxine
- Dexamethasone
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.