What the FDA labels say about taking them together
Aspirin and venlafaxine
Venlafaxine's FDA label of August 15, 2023 names aspirin in its warnings and precautions section; the aspirin label PlainMeds reads does not name venlafaxine. The venlafaxine label: “These studies have also shown that concurrent use of an NSAID or aspirin may potentiate this risk of bleeding.”
Check it at the source: the aspirin FDA label on DailyMed (effective September 9, 2025); the venlafaxine FDA label on DailyMed (effective August 15, 2023, Viatris Specialty LLC).
What does the aspirin label say about venlafaxine?
Aspirin's label (effective September 9, 2025) does not name venlafaxine in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Medique Products Aspirin), Unifirst First Aid Corporation, effective September 9, 2025 (SPL set 9b28fed0-a993-ca72-e053-2995a90ac7fd), via openFDA; the full label on DailyMed
What does the venlafaxine label say about aspirin?
Venlafaxine label, warnings and precautionsIncreased Risk of Bleeding: Concomitant use of aspirin, NSAIDs, other antiplatelet drugs, warfarin, and other anticoagulants may increase risk ( 5.4 ).
Venlafaxine Hydrochloride label (Trigen Laboratories, LLC, July 31, 2025), drug interactionsThese studies have also shown that concurrent use of an NSAID or aspirin may potentiate this risk of bleeding.
Source: FDA drug label (Venlafaxine Hydrochloride, NDA022104), Trigen Laboratories, LLC, effective July 31, 2025 (SPL set fdaed1c2-dd0a-4bf3-975a-86fe3e7f0c97), via openFDA
Source: FDA drug label (Effexor XR), NDA020699 (Upjohn), as published by Viatris Specialty LLC, effective August 15, 2023 (SPL set c848a5d8-ba94-4c84-80e3-0bf35fb8e32e), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Aspirin | Venlafaxine | |
|---|---|---|
| Labeled for | Pain, Cough and cold, Fever | Depression, Anxiety |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $0.0142 per tablet 81 mg tablet | $0.0799 per capsule 75 mg capsule |
| Shortage now | A presentation being discontinued | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once