Venlafaxine and Alprazolam Interaction
Drug interaction information between Venlafaxine and Alprazolam.
Venlafaxine and Alprazolam have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Venlafaxine and Alprazolam. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Venlafaxine does not change how the body breaks down alprazolam. Because of this, the two drugs do not have a significant interaction with each other.
FDA Label Information
This finding was confirmed in vivo by clinical drug interaction studies in which venlafaxine did not inhibit the metabolism of several CYP3A4 substrates, including alprazolam, diazepam, and terfenadine.
Venlafaxine Also Interacts With
- Aspirin moderate
- Phenelzine moderate
- Metoprolol minor
- Fluoxetine minor
- Warfarin minor
Alprazolam Also Interacts With
- Ketoconazole moderate
- Clarithromycin moderate
- Itraconazole moderate
- Digoxin moderate
- Aprepitant moderate
Frequently Asked Questions
What SPL severity band is on file for Venlafaxine + Alprazolam?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Alprazolam has 27 labeled pairs on file vs Venlafaxine's 22. In the minor band specifically: Venlafaxine has 20 (also Metoprolol, Fluoxetine, Warfarin, Ketoconazole); Alprazolam has 20 (also Tramadol, Oxycodone, Morphine, Carbamazepine).
What mechanism field is on file for Venlafaxine and Alprazolam?
Venlafaxine does not change how the body breaks down alprazolam. Because of this, the two drugs do not have a significant interaction with each other.
Alprazolam's labeled portfolio outnumbers Venlafaxine
SPL source-record counts only. This page's band is minor · classes on file: Venlafaxine (Serotonin-Norepinephrine Reuptake Inhibitor (SNRI)); Alprazolam (Benzodiazepine).
0 major · 2 moderate · 20 minor · 22 total
- Other minor peers for Venlafaxine
- Metoprolol
- Fluoxetine
- Warfarin
- Ketoconazole
0 major · 7 moderate · 20 minor · 27 total
- Other minor peers for Alprazolam
- Tramadol
- Oxycodone
- Morphine
- Carbamazepine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.