Venlafaxine and Metoprolol Interaction
Drug interaction information between Venlafaxine and Metoprolol.
Venlafaxine and Metoprolol have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Venlafaxine and Metoprolol. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Venlafaxine can raise the levels of metoprolol in your blood and may also make metoprolol less effective at lowering your blood pressure.
FDA Label Information
Metoprolol Concomitant administration of venlafaxine (50 mg every 8 hours for 5 days) and metoprolol (100 mg every 24 hours for 5 days) to 18 healthy male subjects in a pharmacokinetic interaction study for both drugs resulted in an increase of plasma concentrations of metoprolol by approximately 30 to 40% without altering the plasma concentrations of its active metabolite, α-hydroxymetoprolol. Metoprolol did not alter the pharmacokinetic profile of venlafaxine or its active metabolite, O-desmethylvenlafaxine. Venlafaxine appeared to reduce the blood pressure lowering effect of metoprolol...
Venlafaxine Also Interacts With
- Aspirin moderate
- Phenelzine moderate
- Fluoxetine minor
- Alprazolam minor
- Warfarin minor
Metoprolol Also Interacts With
- Theophylline major
- Clonidine moderate
- Diltiazem moderate
- Verapamil moderate
- Fluoxetine minor
Frequently Asked Questions
What SPL severity band is on file for Venlafaxine + Metoprolol?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Venlafaxine has 22 labeled pairs on file vs Metoprolol's 18. In the minor band specifically: Venlafaxine has 20 (also Fluoxetine, Alprazolam, Warfarin, Ketoconazole); Metoprolol has 14 (also Fluoxetine, Paroxetine, Propafenone, Epinephrine).
What mechanism field is on file for Venlafaxine and Metoprolol?
Venlafaxine can raise the levels of metoprolol in your blood and may also make metoprolol less effective at lowering your blood pressure.
Metoprolol carries more major-labeled pairs than Venlafaxine
SPL source-record counts only. This page's band is minor · classes on file: Venlafaxine (Serotonin-Norepinephrine Reuptake Inhibitor (SNRI)); Metoprolol (Beta-Blocker).
Metoprolol has 1 major-labeled pair vs Venlafaxine's 0. This page itself is in the minor band, not the major band.
0 major · 2 moderate · 20 minor · 22 total
- Other minor peers for Venlafaxine
- Fluoxetine
- Alprazolam
- Warfarin
- Ketoconazole
1 major · 3 moderate · 14 minor · 18 total
- Other minor peers for Metoprolol
- Fluoxetine
- Paroxetine
- Propafenone
- Epinephrine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.