What the FDA labels say about taking them together
Metoprolol and venlafaxine
Venlafaxine's FDA label (Venlafaxine Hydrochloride) of July 31, 2025 names metoprolol in its drug interactions section; the metoprolol labels PlainMeds reads (4) do not name venlafaxine. The venlafaxine label: “Possibly reduced blood-pressure lowering effect despite increased metoprolol plasma levels.”
Check it at the source: the metoprolol FDA label on DailyMed (effective March 3, 2026, Melinta Therapeutics, LLC); the venlafaxine FDA label on DailyMed (effective August 15, 2023, Viatris Specialty LLC).
What does the metoprolol label say about venlafaxine?
Metoprolol's label (effective March 3, 2026) and its 3 other brand-application labels do not name venlafaxine in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (TOPROL XL), Melinta Therapeutics, LLC, effective March 3, 2026 (SPL set 496ddfaa-7c9c-4888-b747-a210249b367a), via openFDA; the full label on DailyMed
What does the venlafaxine label say about metoprolol?
Venlafaxine Hydrochloride label (Trigen Laboratories, LLC, July 31, 2025), drug interactionsPossibly reduced blood-pressure lowering effect despite increased metoprolol plasma levels.
Source: FDA drug label (Venlafaxine Hydrochloride, NDA022104), Trigen Laboratories, LLC, effective July 31, 2025 (SPL set fdaed1c2-dd0a-4bf3-975a-86fe3e7f0c97), via openFDA
Source: FDA drug label (Effexor XR), NDA020699 (Upjohn), as published by Viatris Specialty LLC, effective August 15, 2023 (SPL set c848a5d8-ba94-4c84-80e3-0bf35fb8e32e), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Metoprolol | Venlafaxine | |
|---|---|---|
| Labeled for | High blood pressure, Angina, Heart failure, Heart attack and coronary artery disease | Depression, Anxiety |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $0.085 per tablet 100 mg tablet | $0.0799 per capsule 75 mg capsule |
| Shortage now | A presentation being discontinued | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once