Venlafaxine and Metoprolol Interaction
Drug interaction information between Venlafaxine and Metoprolol.
Venlafaxine and Metoprolol have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Venlafaxine and Metoprolol. Major interactions are generally avoided, moderate ones may need monitoring or a dose adjustment, and minor ones are usually low-risk. This page shows the documented mechanism and guidance. Label-documented interactions are not a complete safety review, so always confirm your own medications with a pharmacist or doctor. Educational information, not medical advice.
How They Interact
Venlafaxine can raise the levels of metoprolol in your blood and may also make metoprolol less effective at lowering your blood pressure.
What To Do
Your doctor should monitor your blood pressure and heart rate regularly. They may need to adjust your metoprolol dose.
FDA Label Information
Metoprolol Concomitant administration of venlafaxine (50 mg every 8 hours for 5 days) and metoprolol (100 mg every 24 hours for 5 days) to 18 healthy male subjects in a pharmacokinetic interaction study for both drugs resulted in an increase of plasma concentrations of metoprolol by approximately 30 to 40% without altering the plasma concentrations of its active metabolite, α-hydroxymetoprolol. Metoprolol did not alter the pharmacokinetic profile of venlafaxine or its active metabolite, O-desmethylvenlafaxine. Venlafaxine appeared to reduce the blood pressure lowering effect of metoprolol...
Venlafaxine Also Interacts With
- Aspirin moderate
- Phenelzine moderate
- Fluoxetine minor
- Alprazolam minor
- Warfarin minor
Metoprolol Also Interacts With
- Theophylline major
- Clonidine moderate
- Diltiazem moderate
- Verapamil moderate
- Fluoxetine minor
Frequently Asked Questions
Can I take Venlafaxine and Metoprolol together?
This is a minor interaction. Your doctor should monitor your blood pressure and heart rate regularly. They may need to adjust your metoprolol dose.
How serious is the interaction between Venlafaxine and Metoprolol?
This interaction is classified as "minor" severity by the FDA. Minor interactions are unlikely to cause significant problems but should still be mentioned to your healthcare provider.
Why do Venlafaxine and Metoprolol interact?
Venlafaxine can raise the levels of metoprolol in your blood and may also make metoprolol less effective at lowering your blood pressure.
Understanding the Venlafaxine and Metoprolol Interaction
FDA-approved prescribing information for these two drugs flags their combination as a minor-severity interaction. Venlafaxine belongs to the Serotonin-Norepinephrine Reuptake Inhibitor (SNRI) class and Metoprolol belongs to the Beta-Blocker class - two categories that can collide when co-prescribed. The mechanism described in FDA labeling is: Venlafaxine can raise the levels of metoprolol in your blood and may also make metoprolol less effective at lowering your blood pressure. Severity tiers matter: major flags generally advise avoidance, moderate flags often require monitoring or dose adjustment, and minor flags may only call for awareness.
Context around a specific patient determines real-world impact. Venlafaxine has 22 total documented interactions on file in this dataset, and Metoprolol has 18. Each additional medication compounds the interaction surface, which is why pharmacists run full-profile checks rather than evaluating one pair at a time. FDA-derived guidance for this pair is: Your doctor should monitor your blood pressure and heart rate regularly. Timing of doses, renal and hepatic function, age, and other concurrent prescriptions all shape whether a labeled interaction matters clinically.
An interaction flag is not a verdict. A large share of labeled interactions are managed routinely in clinical practice, the fix may be as simple as spacing doses or adding a monitoring test. Others require the prescriber to choose a different medication entirely. This page surfaces FDA-sourced labeling and openFDA data for educational purposes only; it is not medical advice and cannot account for your full clinical picture. Never start, stop, or adjust either Venlafaxine or Metoprolol based on a web page, speak with your prescriber or pharmacist before making any change.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. Always consult your healthcare provider about drug interactions.
Read our methodology - how this data is sourced, computed, and verified.