Venlafaxine and Warfarin Interaction
Drug interaction information between Venlafaxine and Warfarin.
Venlafaxine and Warfarin have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Venlafaxine and Warfarin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Venlafaxine can affect how your blood cells help with clotting, which can increase the risk of bleeding when taken with a blood thinner like warfarin.
FDA Label Information
Drugs that Interfere with Hemostasis (e.g., NSAIDs, Aspirin, and Warfarin) Serotonin release by platelets plays an important role in hemostasis. Altered anticoagulant effects, including increased bleeding, have been reported when SSRIs and SNRIs are coadministered with warfarin. Patients receiving warfarin therapy should be carefully monitored when venlafaxine is initiated or discontinued.
Venlafaxine Also Interacts With
- Aspirin moderate
- Phenelzine moderate
- Metoprolol minor
- Fluoxetine minor
- Alprazolam minor
Warfarin Also Interacts With
- Fluoxetine major
- Tamoxifen major
- Ibuprofen moderate
- Aspirin moderate
- Diclofenac moderate
Frequently Asked Questions
What SPL severity band is on file for Venlafaxine + Warfarin?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Warfarin has 163 labeled pairs on file vs Venlafaxine's 22. In the minor band specifically: Venlafaxine has 20 (also Metoprolol, Fluoxetine, Alprazolam, Ketoconazole); Warfarin has 133 (also Atorvastatin, Amlodipine, Omeprazole, Famotidine).
What mechanism field is on file for Venlafaxine and Warfarin?
Venlafaxine can affect how your blood cells help with clotting, which can increase the risk of bleeding when taken with a blood thinner like warfarin.
Warfarin carries more major-labeled pairs than Venlafaxine
SPL source-record counts only. This page's band is minor · classes on file: Venlafaxine (Serotonin-Norepinephrine Reuptake Inhibitor (SNRI)); Warfarin (Vitamin K Antagonist (Anticoagulant)).
Warfarin has 2 major-labeled pairs vs Venlafaxine's 0. This page itself is in the minor band, not the major band.
0 major · 2 moderate · 20 minor · 22 total
- Other minor peers for Venlafaxine
- Metoprolol
- Fluoxetine
- Alprazolam
- Ketoconazole
2 major · 28 moderate · 133 minor · 163 total
- Other minor peers for Warfarin
- Atorvastatin
- Amlodipine
- Omeprazole
- Famotidine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.