Brexpiprazole and Paroxetine Interaction
Drug interaction information between Brexpiprazole and Paroxetine.
Brexpiprazole and Paroxetine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Brexpiprazole and Paroxetine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Paroxetine blocks the liver enzyme that breaks down brexpiprazole, which can lead to higher levels of the drug in your body.
FDA Label Information
7 DRUG INTERACTIONS Factors Dosage Adjustments for REXULTI ( 2.7 ) Strong CYP2D6 REXULTI may be administered without dosage adjustment in patients with MDD when administered with strong CYP2D6 inhibitors (e.g., paroxetine, fluoxetine). Strong CYP2D6 Inhibitors In the clinical studies examining the adjunctive use of REXULTI in the treatment of MDD, dosage was not adjusted for strong CYP2D6 inhibitors (e.g., paroxetine, fluoxetine).
Brexpiprazole Also Interacts With
- Omeprazole minor
- Rosuvastatin minor
- Bupropion minor
- Fluoxetine minor
- Lovastatin minor
Paroxetine Also Interacts With
- Linezolid major
- Pimozide major
- Thioridazine major
- Phenelzine moderate
- Tranylcypromine moderate
Frequently Asked Questions
What SPL severity band is on file for Brexpiprazole + Paroxetine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Paroxetine has 51 labeled pairs on file vs Brexpiprazole's 9. In the minor band specifically: Brexpiprazole has 9 (also Omeprazole, Rosuvastatin, Bupropion, Fluoxetine); Paroxetine has 44 (also Buspirone, Clopidogrel, Aspirin, Venlafaxine).
What mechanism field is on file for Brexpiprazole and Paroxetine?
Paroxetine blocks the liver enzyme that breaks down brexpiprazole, which can lead to higher levels of the drug in your body.
Paroxetine carries more major-labeled pairs than Brexpiprazole
SPL source-record counts only. This page's band is minor · classes on file: Brexpiprazole (Atypical Antipsychotic); Paroxetine (Selective Serotonin Reuptake Inhibitor (SSRI)).
Paroxetine has 3 major-labeled pairs vs Brexpiprazole's 0. This page itself is in the minor band, not the major band.
0 major · 0 moderate · 9 minor · 9 total
- Other minor peers for Brexpiprazole
- Omeprazole
- Rosuvastatin
- Bupropion
- Fluoxetine
3 major · 4 moderate · 44 minor · 51 total
- Other minor peers for Paroxetine
- Buspirone
- Clopidogrel
- Aspirin
- Venlafaxine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.