Brexpiprazole and Rosuvastatin Interaction
Drug interaction information between Brexpiprazole and Rosuvastatin.
Brexpiprazole and Rosuvastatin have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Brexpiprazole and Rosuvastatin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Brexpiprazole does not interfere with the specific proteins the body uses to move and process rosuvastatin.
FDA Label Information
Additionally, no dosage adjustment for substrates of CYP2D6 (e.g., dextromethorphan), CYP3A4 (e.g., lovastatin), CYP2B6 (e.g., bupropion), BCRP (e.g., rosuvastatin), or P-gp (e.g., fexofenadine) is required when administered concomitantly with REXULTI.
Brexpiprazole Also Interacts With
- Omeprazole minor
- Bupropion minor
- Fluoxetine minor
- Paroxetine minor
- Lovastatin minor
Rosuvastatin Also Interacts With
- Sofosbuvir/Velpatasvir major
- Glecaprevir/Pibrentasvir major
- Febuxostat major
- Cyclosporine moderate
- Ledipasvir/Sofosbuvir moderate
Frequently Asked Questions
What SPL severity band is on file for Brexpiprazole + Rosuvastatin?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Rosuvastatin has 21 labeled pairs on file vs Brexpiprazole's 9. In the minor band specifically: Brexpiprazole has 9 (also Omeprazole, Bupropion, Fluoxetine, Paroxetine); Rosuvastatin has 10 (also Fenofibrate, Warfarin, Darunavir, Estradiol).
What mechanism field is on file for Brexpiprazole and Rosuvastatin?
Brexpiprazole does not interfere with the specific proteins the body uses to move and process rosuvastatin.
Rosuvastatin carries more major-labeled pairs than Brexpiprazole
SPL source-record counts only. This page's band is minor · classes on file: Brexpiprazole (Atypical Antipsychotic); Rosuvastatin (HMG-CoA Reductase Inhibitor (Statin)).
Rosuvastatin has 3 major-labeled pairs vs Brexpiprazole's 0. This page itself is in the minor band, not the major band.
0 major · 0 moderate · 9 minor · 9 total
- Other minor peers for Brexpiprazole
- Omeprazole
- Bupropion
- Fluoxetine
- Paroxetine
3 major · 8 moderate · 10 minor · 21 total
- Other minor peers for Rosuvastatin
- Fenofibrate
- Warfarin
- Darunavir
- Estradiol
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.