Brexpiprazole and Bupropion Interaction
Drug interaction information between Brexpiprazole and Bupropion.
Brexpiprazole and Bupropion have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Brexpiprazole and Bupropion. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Brexpiprazole does not change how the liver enzymes break down bupropion in the body.
FDA Label Information
Additionally, no dosage adjustment for substrates of CYP2D6 (e.g., dextromethorphan), CYP3A4 (e.g., lovastatin), CYP2B6 (e.g., bupropion), BCRP (e.g., rosuvastatin), or P-gp (e.g., fexofenadine) is required when administered concomitantly with REXULTI.
Brexpiprazole Also Interacts With
- Omeprazole minor
- Rosuvastatin minor
- Fluoxetine minor
- Paroxetine minor
- Lovastatin minor
Bupropion Also Interacts With
- Tranylcypromine major
- Theophylline moderate
- Isavuconazonium moderate
- Metoprolol minor
- Sertraline minor
Frequently Asked Questions
What SPL severity band is on file for Brexpiprazole + Bupropion?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Bupropion has 35 labeled pairs on file vs Brexpiprazole's 9. In the minor band specifically: Brexpiprazole has 9 (also Omeprazole, Rosuvastatin, Fluoxetine, Paroxetine); Bupropion has 32 (also Metoprolol, Sertraline, Fluoxetine, Clopidogrel).
What mechanism field is on file for Brexpiprazole and Bupropion?
Brexpiprazole does not change how the liver enzymes break down bupropion in the body.
Bupropion carries more major-labeled pairs than Brexpiprazole
SPL source-record counts only. This page's band is minor · classes on file: Brexpiprazole (Atypical Antipsychotic); Bupropion (Norepinephrine-Dopamine Reuptake Inhibitor (NDRI)).
Bupropion has 1 major-labeled pair vs Brexpiprazole's 0. This page itself is in the minor band, not the major band.
0 major · 0 moderate · 9 minor · 9 total
- Other minor peers for Brexpiprazole
- Omeprazole
- Rosuvastatin
- Fluoxetine
- Paroxetine
1 major · 2 moderate · 32 minor · 35 total
- Other minor peers for Bupropion
- Metoprolol
- Sertraline
- Fluoxetine
- Clopidogrel
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.