brexpiprazole vs omeprazole
According to this portal's Publishing Organization, this page was last reviewed in August 2026 against our methodology. Figures and extracts on this site, including tables above 1,000 rows when the corpus is that large, are the publisher's responsibility.
Side-by-side comparison of brexpiprazole and omeprazole. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
minor Known Drug Interaction
7.2 Drugs Having No Clinically Important Interactions with REXULTI Based on pharmacokinetic studies, no dosage adjustment of REXULTI is required when administered concomitantly with CYP2B6 inhibitors (e.g., ticlopidine) or gastric pH modifiers (e.g., omeprazole).
Rexulti
Prilosec
Rexulti is a medication used to treat certain mental health conditions. It can help with depression, schizophrenia, and agitation related to Alzheimer's disease.
Omeprazole (Prilosec) is a medicine that reduces the amount of acid in your stomach. It belongs to a class of drugs called proton pump inhibitors (PPIs).
Rexulti can be used with antidepressants to treat major depressive disorder in adults. It can also treat schizophrenia in adults and children 13 years and older. Additionally, Rexulti can help manage agitation in people with dementia due to Alzheimer's disease. Rexulti should not be used as needed for agitation related to dementia.
This medicine treats frequent heartburn, which is heartburn that occurs 2 or more days a week. It is not meant to give you immediate relief from heartburn. It may take 1 to 4 days for the medicine to fully work.
Rexulti affects the balance of certain natural chemicals in the brain. These chemicals, called neurotransmitters, include dopamine and serotonin. By affecting these chemicals, Rexulti can help improve mood, thinking, and behavior.
Omeprazole works by blocking the production of acid in your stomach. It does this by targeting the cells that make stomach acid. This helps to reduce heartburn symptoms.
- • Weight gain
- • Feeling sleepy
- • Restlessness or feeling like you need to move
- • Headache
- Weight Increased 1,673
- Akathisia 854
- Tremor 630
- Anxiety 591
- Tardive Dyskinesia 590
- Fatigue 19,901
- Nausea 19,842
- Diarrhoea 19,627
- Dyspnoea 16,336
- Headache 14,629
Elderly patients with dementia-related psychosis who are treated with antipsychotic drugs have an increased risk of death. Rexulti is not approved to treat dementia-related psychosis unless it is related to agitation from Alzheimer's disease. Antidepressants may increase the risk of suicidal thoughts and behaviors in young adults and children. Tell your doctor right away if you have thoughts of harming yourself.
Children under 18 should ask a doctor before use. Heartburn in children may be a sign of a serious condition.
Tell your doctor if you are pregnant or plan to become pregnant. Babies born to mothers who take Rexulti in the last 3 months of pregnancy may have withdrawal symptoms or other problems after birth. There is a pregnancy registry to monitor outcomes in women exposed to Rexulti during pregnancy. You can contact the registry at 1-866-961-2388.
Talk to your doctor if you are pregnant or breastfeeding before taking this medicine. It is important to weigh the benefits and risks with your doctor.
Also Compare, Nearby Drugs
Compare brexpiprazole with
Compare omeprazole with
How to Read This brexpiprazole vs omeprazole Comparison
brexpiprazole is classified in the Atypical Antipsychotic drug class, while omeprazole sits within the Proton Pump Inhibitor (PPI) class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are split between OTC and prescription status, which affects access and supervision.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, brexpiprazole has 4,338 submissions while omeprazole has 90,335. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known minor interaction flagged in FDA labeling, attributed to omeprazole changes the acid levels in the stomach, but this does not affect how the body absorbs or processes brexpiprazole.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot represent individual circumstances. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This registry does not provide medical, treatment, substitution, or medication-change directions for brexpiprazole or omeprazole.
Registry boundary: This comparison displays source-record fields and does not provide individualized medical direction.