Brexpiprazole and Lovastatin Interaction
Drug interaction information between Brexpiprazole and Lovastatin.
Brexpiprazole and Lovastatin have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Brexpiprazole and Lovastatin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Brexpiprazole does not significantly change how your body processes lovastatin through the liver.
FDA Label Information
Additionally, no dosage adjustment for substrates of CYP2D6 (e.g., dextromethorphan), CYP3A4 (e.g., lovastatin), CYP2B6 (e.g., bupropion), BCRP (e.g., rosuvastatin), or P-gp (e.g., fexofenadine) is required when administered concomitantly with REXULTI.
Brexpiprazole Also Interacts With
- Omeprazole minor
- Rosuvastatin minor
- Bupropion minor
- Fluoxetine minor
- Paroxetine minor
Lovastatin Also Interacts With
- Darunavir major
- Nirmatrelvir/Ritonavir major
- Spironolactone moderate
- Ketoconazole moderate
- Verapamil moderate
Frequently Asked Questions
What SPL severity band is on file for Brexpiprazole + Lovastatin?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Lovastatin has 30 labeled pairs on file vs Brexpiprazole's 9. In the minor band specifically: Brexpiprazole has 9 (also Omeprazole, Rosuvastatin, Bupropion, Fluoxetine); Lovastatin has 11 (also Glipizide, Propranolol, Warfarin, Testosterone).
What mechanism field is on file for Brexpiprazole and Lovastatin?
Brexpiprazole does not significantly change how your body processes lovastatin through the liver.
Lovastatin carries more major-labeled pairs than Brexpiprazole
SPL source-record counts only. This page's band is minor · classes on file: Brexpiprazole (Atypical Antipsychotic); Lovastatin (HMG-CoA Reductase Inhibitor (Statin)).
Lovastatin has 2 major-labeled pairs vs Brexpiprazole's 0. This page itself is in the minor band, not the major band.
0 major · 0 moderate · 9 minor · 9 total
- Other minor peers for Brexpiprazole
- Omeprazole
- Rosuvastatin
- Bupropion
- Fluoxetine
2 major · 17 moderate · 11 minor · 30 total
- Other minor peers for Lovastatin
- Glipizide
- Propranolol
- Warfarin
- Testosterone
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.