What the FDA labels say about taking them together
Atomoxetine and fluoxetine
Atomoxetine's FDA label of May 25, 2026 names fluoxetine in its drug interactions section; the fluoxetine label PlainMeds reads does not name atomoxetine. The atomoxetine label: “Dosage adjustment of atomoxetine may be necessary when coadministered with potent CYP2D6 inhibitors or when administered to CYP2D6 PMs..”
Check it at the source: the atomoxetine FDA label on DailyMed (effective May 25, 2026, Camber Pharmaceuticals, Inc.); the fluoxetine FDA label on DailyMed (effective January 8, 2026, Dista Products Company).
What does the atomoxetine label say about fluoxetine?
Atomoxetine label, drug interactionsInhibitors on Atomoxetine In extensive metabolizers (EMs), inhibitors of CYP2D6 (e.g., paroxetine, fluoxetine, and quinidine) increase atomoxetine steady-state plasma concentrations to exposures similar to those observed in poor metabolizers (PMs).
Atomoxetine label, warnings and precautionsDosage adjustment of atomoxetine may be necessary when coadministered with potent CYP2D6 inhibitors (e.g., paroxetine, fluoxetine, and quinidine) or when administered to CYP2D6 PMs. [see Dosage and Administration ( 2.5 ) and Drug Interactions ( 7.2 )].
Source: FDA drug label (Atomoxetine), ANDA202682 (Hetero Labs Ltd V), as published by Camber Pharmaceuticals, Inc., effective May 25, 2026 (SPL set f266ab7b-5a68-42b5-b204-e3249bea0aed), via openFDA; the full label on DailyMed
What does the fluoxetine label say about atomoxetine?
Fluoxetine's label (effective January 8, 2026) does not name atomoxetine in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Prozac), NDA018936 (Eli Lilly And Co), as published by Dista Products Company, effective January 8, 2026 (SPL set c88f33ed-6dfb-4c5e-bc01-d8e36dd97299), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Atomoxetine | Fluoxetine | |
|---|---|---|
| Labeled for | ADHD | Depression, Anxiety, Bipolar disorder |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $0.442 per capsule 40 mg capsule | $0.0519 per capsule 40 mg capsule |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once