atomoxetine vs omeprazole

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Side-by-side comparison of atomoxetine and omeprazole. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.

minor Known Drug Interaction

7.9 Drugs that Affect Gastric pH Drugs that elevate gastric pH (magnesium hydroxide/aluminum hydroxide, omeprazole) had no effect on atomoxetine bioavailability.

Drug Class
atomoxetine Selective Norepinephrine Reuptake Inhibitor
omeprazole Proton Pump Inhibitor (PPI)
Type
atomoxetine Prescription
omeprazole Over-the-Counter
Summary
atomoxetine

Atomoxetine (Strattera) is a medicine that can help people with Attention-Deficit/Hyperactivity Disorder (ADHD). It works by affecting a chemical in the brain called norepinephrine.

omeprazole

Omeprazole (Prilosec) is a medicine that reduces the amount of acid in your stomach. It belongs to a class of drugs called proton pump inhibitors (PPIs).

What It Treats
atomoxetine

Atomoxetine is used to treat Attention-Deficit/Hyperactivity Disorder (ADHD). ADHD can cause you to be hyperactive, impulsive, and have trouble paying attention. This medicine can help you focus, be less impulsive, and feel calmer. It is for both kids and adults.

omeprazole

This medicine treats frequent heartburn, which is heartburn that occurs 2 or more days a week. It is not meant to give you immediate relief from heartburn. It may take 1 to 4 days for the medicine to fully work.

How It Works
atomoxetine

Atomoxetine works by increasing the amount of norepinephrine in your brain. Norepinephrine is a chemical that helps you pay attention and control your impulses. By increasing norepinephrine, atomoxetine can improve ADHD symptoms.

omeprazole

Omeprazole works by blocking the production of acid in your stomach. It does this by targeting the cells that make stomach acid. This helps to reduce heartburn symptoms.

Common Side Effects
atomoxetine
  • Feeling sick to your stomach
  • Throwing up
  • Feeling tired
  • Not feeling hungry
  • Belly pain
omeprazole
  • Headache
FAERS Reports
atomoxetine
  • Nausea 431
  • Headache 407
  • Fatigue 401
  • Condition Aggravated 395
  • Hypertension 388
omeprazole
  • Fatigue 19,901
  • Nausea 19,842
  • Diarrhoea 19,627
  • Dyspnoea 16,336
  • Headache 14,629
Serious Warnings
atomoxetine

Atomoxetine can increase the risk of suicidal thoughts in children and teenagers. Watch carefully for worsening mood or any unusual changes in behavior. Tell your doctor right away if you have any suicidal thoughts or feelings.

omeprazole

Children under 18 should ask a doctor before use. Heartburn in children may be a sign of a serious condition.

Pregnancy
atomoxetine

Tell your doctor if you are pregnant or plan to become pregnant. It is not known if atomoxetine will harm your unborn baby. There is a pregnancy registry for women who take ADHD medicines during pregnancy. Talk to your doctor about how to register.

omeprazole

Talk to your doctor if you are pregnant or breastfeeding before taking this medicine. It is important to weigh the benefits and risks with your doctor.

Also Compare, Nearby Drugs

How to Read This atomoxetine vs omeprazole Comparison

atomoxetine is classified in the Selective Norepinephrine Reuptake Inhibitor drug class, while omeprazole sits within the Proton Pump Inhibitor (PPI) class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are split between OTC and prescription status, which affects access and supervision.

Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, atomoxetine has 2,022 submissions while omeprazole has 90,335. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known minor interaction flagged in FDA labeling, attributed to omeprazole changes the acid levels in the stomach, but this does not change how the body absorbs atomoxetine.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.

A table cannot represent individual circumstances. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This registry does not provide medical, treatment, substitution, or medication-change directions for atomoxetine or omeprazole.

Registry boundary: This comparison displays source-record fields and does not provide individualized medical direction.