Nortriptyline and Fluconazole Interaction
Drug interaction information between Nortriptyline and Fluconazole.
Nortriptyline and Fluconazole have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Nortriptyline and Fluconazole. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Fluconazole slows down how the body breaks down nortriptyline, which causes the drug to stay in the system longer.
FDA Label Information
Amitriptyline, nortriptyline : Fluconazole increases the effect of amitriptyline and nortriptyline. 5-Nortriptyline and/or S-amitriptyline may be measured at initiation of the combination therapy and after 1 week. Dosage of amitriptyline/nortriptyline should be adjusted, if necessary.
Nortriptyline Also Interacts With
- Bupropion minor
- Carbamazepine minor
- Darunavir minor
- Dopamine minor
- Norepinephrine minor
Fluconazole Also Interacts With
- Pimozide major
- Clarithromycin major
- Eplerenone major
- Atorvastatin moderate
- Simvastatin moderate
Frequently Asked Questions
What SPL severity band is on file for Nortriptyline + Fluconazole?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Fluconazole has 67 labeled pairs on file vs Nortriptyline's 8. In the minor band specifically: Nortriptyline has 8 (also Bupropion, Carbamazepine, Darunavir, Dopamine); Fluconazole has 57 (also Amlodipine, Losartan, Hydrochlorothiazide, Meloxicam).
What mechanism field is on file for Nortriptyline and Fluconazole?
Fluconazole slows down how the body breaks down nortriptyline, which causes the drug to stay in the system longer.
Fluconazole carries more major-labeled pairs than Nortriptyline
SPL source-record counts only. This page's band is minor · classes on file: Nortriptyline (Tricyclic Antidepressant (TCA)); Fluconazole (Azole Antifungal).
Fluconazole has 3 major-labeled pairs vs Nortriptyline's 0. This page itself is in the minor band, not the major band.
0 major · 0 moderate · 8 minor · 8 total
- Other minor peers for Nortriptyline
- Bupropion
- Carbamazepine
- Darunavir
- Dopamine
3 major · 7 moderate · 57 minor · 67 total
- Other minor peers for Fluconazole
- Amlodipine
- Losartan
- Hydrochlorothiazide
- Meloxicam
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.