Nortriptyline and Bupropion Interaction
Drug interaction information between Nortriptyline and Bupropion.
Nortriptyline and Bupropion have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Nortriptyline and Bupropion. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Bupropion blocks the enzyme that clears nortriptyline from your body, which can cause nortriptyline levels to rise.
FDA Label Information
( 7.1 ) Drugs metabolized by CYP2D6: Bupropion inhibits CYP2D6 and can increase concentrations of: antidepressants (e.g., venlafaxine, nortriptyline, imipramine, desipramine, paroxetine, fluoxetine, sertraline), antipsychotics (e.g., haloperidol, risperidone, thioridazine), beta-blockers (e.g., metoprolol), and Type 1C antiarrhythmics (e.g., propafenone, flecainide). Such drugs include certain antidepressants (e.g., venlafaxine, nortriptyline, imipramine, desipramine, paroxetine, fluoxetine, and sertraline), antipsychotics (e.g., haloperidol, risperidone, and thioridazine), beta-blockers...
Nortriptyline Also Interacts With
- Carbamazepine minor
- Darunavir minor
- Dopamine minor
- Fluconazole minor
- Norepinephrine minor
Bupropion Also Interacts With
- Tranylcypromine major
- Theophylline moderate
- Isavuconazonium moderate
- Metoprolol minor
- Sertraline minor
Frequently Asked Questions
What SPL severity band is on file for Nortriptyline + Bupropion?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Bupropion has 35 labeled pairs on file vs Nortriptyline's 8. In the minor band specifically: Nortriptyline has 8 (also Carbamazepine, Darunavir, Dopamine, Fluconazole); Bupropion has 32 (also Metoprolol, Sertraline, Fluoxetine, Clopidogrel).
What mechanism field is on file for Nortriptyline and Bupropion?
Bupropion blocks the enzyme that clears nortriptyline from your body, which can cause nortriptyline levels to rise.
Bupropion carries more major-labeled pairs than Nortriptyline
SPL source-record counts only. This page's band is minor · classes on file: Nortriptyline (Tricyclic Antidepressant (TCA)); Bupropion (Norepinephrine-Dopamine Reuptake Inhibitor (NDRI)).
Bupropion has 1 major-labeled pair vs Nortriptyline's 0. This page itself is in the minor band, not the major band.
0 major · 0 moderate · 8 minor · 8 total
- Other minor peers for Nortriptyline
- Carbamazepine
- Darunavir
- Dopamine
- Fluconazole
1 major · 2 moderate · 32 minor · 35 total
- Other minor peers for Bupropion
- Metoprolol
- Sertraline
- Fluoxetine
- Clopidogrel
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.