fluconazole vs nortriptyline
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Side-by-side comparison of fluconazole and nortriptyline. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
minor Known Drug Interaction
Amitriptyline, nortriptyline : Fluconazole increases the effect of amitriptyline and nortriptyline. 5-Nortriptyline and/or S-amitriptyline may be measured at initiation of the combination therapy and after 1 week. Dosage of amitriptyline/nortriptyline should be adjusted, if necessary.
Diflucan
Pamelor
Fluconazole is an antifungal medicine. It is used to treat infections caused by fungus.
Nortriptyline (Pamelor) is a medicine used to treat depression. It can help improve your mood.
Fluconazole treats vaginal yeast infections. It also treats yeast infections in the mouth and esophagus. Fluconazole can also treat urinary tract infections, peritonitis, systemic Candida infections, and pneumonia. It can also treat cryptococcal meningitis. Fluconazole can also prevent candidiasis in patients undergoing bone marrow transplantation.
Nortriptyline is used to relieve the symptoms of depression. It may work better for some types of depression than others. Talk to your doctor to see if nortriptyline is right for you.
Fluconazole works by stopping the growth of fungi. It blocks the fungus from producing a substance it needs to grow. This helps to clear up the infection.
Nortriptyline is a tricyclic antidepressant (TCA). It works by increasing the levels of certain natural chemicals in the brain. These chemicals help regulate mood.
- • Headache
- • Nausea
- • Abdominal pain
- • Dry mouth
- • Blurred vision
- • Constipation
- • Drowsiness
- • Dizziness
- Pyrexia 4,121
- Nausea 3,697
- Diarrhoea 3,538
- Fatigue 3,151
- Pain 3,123
- Pain 695
- Headache 679
- Fatigue 593
- Nausea 513
- Hyperhidrosis 485
Coadministration of other drugs known to prolong the QT interval and which are metabolized via the enzyme CYP3A4 such as erythromycin, pimozide, and quinidine are contraindicated in patients receiving fluconazole.
Antidepressants may increase the risk of suicidal thoughts or actions in children, teenagers, and young adults. Your doctor will monitor you closely for worsening depression or unusual changes in behavior. Families and caregivers should also watch for these changes.
Tell your doctor if you are pregnant or plan to become pregnant. Fluconazole may not be safe for your baby. Talk to your doctor about breastfeeding while taking fluconazole.
Tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding. Nortriptyline may not be safe for your baby. Talk to your doctor about the risks and benefits.
Also Compare, Nearby Drugs
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How to Read This fluconazole vs nortriptyline Comparison
fluconazole is classified in the Azole Antifungal drug class, while nortriptyline sits within the Tricyclic Antidepressant (TCA) class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, fluconazole has 17,630 submissions while nortriptyline has 2,965. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known minor interaction flagged in FDA labeling, attributed to fluconazole slows down how the body breaks down nortriptyline, which causes the drug to stay in the system longer.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot represent individual circumstances. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This registry does not provide medical, treatment, substitution, or medication-change directions for fluconazole or nortriptyline.
Registry boundary: This comparison displays source-record fields and does not provide individualized medical direction.