Nortriptyline and Darunavir Interaction
Drug interaction information between Nortriptyline and Darunavir.
Nortriptyline and Darunavir have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Nortriptyline and Darunavir. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Darunavir slows down the body's ability to get rid of this antidepressant, leading to higher levels in your blood. This can cause side effects like nausea, dizziness, and fainting.
FDA Label Information
Tricyclic Antidepressants (TCAs): amitriptyline, desipramine, imipramine, nortriptyline ↑ amitriptyline ↑ desipramine ↑ imipramine ↑ nortriptyline Use a lower dose of the tricyclic antidepressants and trazodone due to potential increased adverse events such as nausea, dizziness, hypotension and syncope.
Nortriptyline Also Interacts With
- Bupropion minor
- Carbamazepine minor
- Dopamine minor
- Fluconazole minor
- Norepinephrine minor
Darunavir Also Interacts With
- Lovastatin major
- Sildenafil major
- Lurasidone major
- Pimozide major
- Midazolam major
Frequently Asked Questions
What SPL severity band is on file for Nortriptyline + Darunavir?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Darunavir has 101 labeled pairs on file vs Nortriptyline's 8. In the minor band specifically: Nortriptyline has 8 (also Bupropion, Carbamazepine, Dopamine, Fluconazole); Darunavir has 70 (also Amlodipine, Metoprolol, Sertraline, Rosuvastatin).
What mechanism field is on file for Nortriptyline and Darunavir?
Darunavir slows down the body's ability to get rid of this antidepressant, leading to higher levels in your blood. This can cause side effects like nausea, dizziness, and fainting.
Darunavir carries more major-labeled pairs than Nortriptyline
SPL source-record counts only. This page's band is minor · classes on file: Nortriptyline (Tricyclic Antidepressant (TCA)); Darunavir (HIV Protease Inhibitor).
Darunavir has 15 major-labeled pairs vs Nortriptyline's 0. This page itself is in the minor band, not the major band.
0 major · 0 moderate · 8 minor · 8 total
- Other minor peers for Nortriptyline
- Bupropion
- Carbamazepine
- Dopamine
- Fluconazole
15 major · 16 moderate · 70 minor · 101 total
- Other minor peers for Darunavir
- Amlodipine
- Metoprolol
- Sertraline
- Rosuvastatin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.