Moxifloxacin and Sotalol Interaction
Drug interaction information between Moxifloxacin and Sotalol.
Moxifloxacin and Sotalol have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Moxifloxacin and Sotalol. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Both drugs can change the electrical timing of your heartbeat, which might increase the risk of a dangerous heart rhythm.
FDA Label Information
Sotalol, a Class III antiarrhythmic, has been shown to further increase the QTc interval when combined with high doses of intravenous moxifloxacin hydrochloride in dogs.
Moxifloxacin Also Interacts With
- Lefamulin moderate
- Warfarin minor
- Sucralfate minor
- Zinc Sulfate minor
- Clozapine minor
Sotalol Also Interacts With
- Clonidine moderate
- Amiodarone moderate
- Clarithromycin moderate
- Digoxin moderate
- Albuterol minor
Frequently Asked Questions
What SPL severity band is on file for Moxifloxacin + Sotalol?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Sotalol has 13 labeled pairs on file vs Moxifloxacin's 10. In the minor band specifically: Moxifloxacin has 9 (also Warfarin, Sucralfate, Zinc Sulfate, Clozapine); Sotalol has 9 (also Albuterol, Diltiazem, Verapamil, Clozapine).
What mechanism field is on file for Moxifloxacin and Sotalol?
Both drugs can change the electrical timing of your heartbeat, which might increase the risk of a dangerous heart rhythm.
Sotalol's labeled portfolio outnumbers Moxifloxacin
SPL source-record counts only. This page's band is minor · classes on file: Moxifloxacin (Fluoroquinolone Antibiotic); Sotalol (Class III Antiarrhythmic / Beta-Blocker).
0 major · 1 moderate · 9 minor · 10 total
- Other minor peers for Moxifloxacin
- Warfarin
- Sucralfate
- Zinc Sulfate
- Clozapine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.