Moxifloxacin and Warfarin Interaction
Drug interaction information between Moxifloxacin and Warfarin.
Moxifloxacin and Warfarin have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Moxifloxacin and Warfarin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Moxifloxacin can increase the blood-thinning effects of warfarin, which makes it easier for you to bleed or bruise.
FDA Label Information
( 2.2 , 7.1 , 12.3 ) Warfarin Anticoagulant effect enhanced. 7.2 Warfarin Fluoroquinolones, including moxifloxacin hydrochloride, have been reported to enhance the anticoagulant effects of warfarin or its derivatives in the patient population. Therefore the prothrombin time, International Normalized Ratio (INR), or other suitable anticoagulation tests should be closely monitored if moxifloxacin hydrochloride is administered concomitantly with warfarin or its derivatives [see Adverse Reactions (6.2) and Clinical Pharmacology (12.3) ].
Moxifloxacin Also Interacts With
- Lefamulin moderate
- Sotalol minor
- Sucralfate minor
- Zinc Sulfate minor
- Clozapine minor
Warfarin Also Interacts With
- Fluoxetine major
- Tamoxifen major
- Ibuprofen moderate
- Aspirin moderate
- Diclofenac moderate
Frequently Asked Questions
What SPL severity band is on file for Moxifloxacin + Warfarin?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Warfarin has 163 labeled pairs on file vs Moxifloxacin's 10. In the minor band specifically: Moxifloxacin has 9 (also Sotalol, Sucralfate, Zinc Sulfate, Clozapine); Warfarin has 133 (also Atorvastatin, Amlodipine, Omeprazole, Famotidine).
What mechanism field is on file for Moxifloxacin and Warfarin?
Moxifloxacin can increase the blood-thinning effects of warfarin, which makes it easier for you to bleed or bruise.
Warfarin carries more major-labeled pairs than Moxifloxacin
SPL source-record counts only. This page's band is minor · classes on file: Moxifloxacin (Fluoroquinolone Antibiotic); Warfarin (Vitamin K Antagonist (Anticoagulant)).
Warfarin has 2 major-labeled pairs vs Moxifloxacin's 0. This page itself is in the minor band, not the major band.
0 major · 1 moderate · 9 minor · 10 total
- Other minor peers for Moxifloxacin
- Sotalol
- Sucralfate
- Zinc Sulfate
- Clozapine
2 major · 28 moderate · 133 minor · 163 total
- Other minor peers for Warfarin
- Atorvastatin
- Amlodipine
- Omeprazole
- Famotidine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.