Moxifloxacin and Sucralfate Interaction
Drug interaction information between Moxifloxacin and Sucralfate.
Moxifloxacin and Sucralfate have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Moxifloxacin and Sucralfate. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Sucralfate contains metals that stick to the antibiotic in your stomach, which stops the medicine from being absorbed into your body.
FDA Label Information
7 DRUG INTERACTIONS Interacting Drug Interaction Multivalent cation-containing products including: antacids, sucralfate, multivitamins Decreased moxifloxacin hydrochloride absorption. ( 5.12 , 7.3 ) 7.1 Antacids, Sucralfate, Multivitamins and Other Products Containing Multivalent Cations Fluoroquinolones, including moxifloxacin hydrochloride, form chelates with alkaline earth and transition metal cations. Oral administration of moxifloxacin hydrochloride with antacids containing aluminum or magnesium, with sucralfate, with metal cations such as iron, or with multivitamins containing iron...
Moxifloxacin Also Interacts With
- Lefamulin moderate
- Warfarin minor
- Sotalol minor
- Zinc Sulfate minor
- Clozapine minor
Sucralfate Also Interacts With
- Theophylline major
- Naproxen moderate
- Warfarin minor
- Ketoconazole minor
- Ciprofloxacin minor
Frequently Asked Questions
What SPL severity band is on file for Moxifloxacin + Sucralfate?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Sucralfate has 20 labeled pairs on file vs Moxifloxacin's 10. In the minor band specifically: Moxifloxacin has 9 (also Warfarin, Sotalol, Zinc Sulfate, Clozapine); Sucralfate has 18 (also Warfarin, Ketoconazole, Ciprofloxacin, Ofloxacin).
What mechanism field is on file for Moxifloxacin and Sucralfate?
Sucralfate contains metals that stick to the antibiotic in your stomach, which stops the medicine from being absorbed into your body.
Sucralfate carries more major-labeled pairs than Moxifloxacin
SPL source-record counts only. This page's band is minor · classes on file: Moxifloxacin (Fluoroquinolone Antibiotic); Sucralfate (Mucosal Protective Agent).
Sucralfate has 1 major-labeled pair vs Moxifloxacin's 0. This page itself is in the minor band, not the major band.
0 major · 1 moderate · 9 minor · 10 total
- Other minor peers for Moxifloxacin
- Warfarin
- Sotalol
- Zinc Sulfate
- Clozapine
1 major · 1 moderate · 18 minor · 20 total
- Other minor peers for Sucralfate
- Warfarin
- Ketoconazole
- Ciprofloxacin
- Ofloxacin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.