Moxifloxacin and Lefamulin Interaction
Drug interaction information between Moxifloxacin and Lefamulin.
Moxifloxacin and Lefamulin have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Moxifloxacin and Lefamulin. Major interactions are generally avoided, moderate ones may need monitoring or a dose adjustment, and minor ones are usually low-risk. This page shows the documented mechanism and guidance. Label-documented interactions are not a complete safety review, so always confirm your own medications with a pharmacist or doctor. Educational information, not medical advice.
How They Interact
Both of these medicines can affect the electrical timing of your heart. Taking them together increases the risk of developing a life-threatening irregular heartbeat.
What To Do
Avoid using these two medications at the same time. Your doctor should look for a different treatment to avoid this heart risk.
FDA Label Information
Therefore, avoid concomitant use of XENLETA Injection and XENLETA Tablets with such drugs (for example, Class IA and III antiarrhythmics, antipsychotics, erythromycin, moxifloxacin, tricyclic antidepressants).
Moxifloxacin Also Interacts With
- Warfarin minor
- Sotalol minor
- Sucralfate minor
- Zinc Sulfate minor
- Clozapine minor
Lefamulin Also Interacts With
- Erythromycin moderate
- Simvastatin minor
- Alprazolam minor
- Diltiazem minor
- Verapamil minor
Frequently Asked Questions
Can I take Moxifloxacin and Lefamulin together?
This is a moderate interaction. Avoid using these two medications at the same time. Your doctor should look for a different treatment to avoid this heart risk.
How serious is the interaction between Moxifloxacin and Lefamulin?
This interaction is classified as "moderate" severity by the FDA. Moderate interactions may worsen your condition or change how your medications work.
Why do Moxifloxacin and Lefamulin interact?
Both of these medicines can affect the electrical timing of your heart. Taking them together increases the risk of developing a life-threatening irregular heartbeat.
Understanding the Moxifloxacin and Lefamulin Interaction
FDA-approved prescribing information for these two drugs flags their combination as a moderate-severity interaction. Moxifloxacin belongs to the Fluoroquinolone Antibiotic class and Lefamulin belongs to the Pleuromutilin Antibiotic class - two categories that can collide when co-prescribed. The mechanism described in FDA labeling is: Both of these medicines can affect the electrical timing of your heart. Severity tiers matter: major flags generally advise avoidance, moderate flags often require monitoring or dose adjustment, and minor flags may only call for awareness.
Context around a specific patient determines real-world impact. Moxifloxacin has 10 total documented interactions on file in this dataset, and Lefamulin has 7. Each additional medication compounds the interaction surface, which is why pharmacists run full-profile checks rather than evaluating one pair at a time. FDA-derived guidance for this pair is: Avoid using these two medications at the same time. Timing of doses, renal and hepatic function, age, and other concurrent prescriptions all shape whether a labeled interaction matters clinically.
An interaction flag is not a verdict. A large share of labeled interactions are managed routinely in clinical practice, the fix may be as simple as spacing doses or adding a monitoring test. Others require the prescriber to choose a different medication entirely. This page surfaces FDA-sourced labeling and openFDA data for educational purposes only; it is not medical advice and cannot account for your full clinical picture. Never start, stop, or adjust either Moxifloxacin or Lefamulin based on a web page, speak with your prescriber or pharmacist before making any change.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. Always consult your healthcare provider about drug interactions.
Read our methodology - how this data is sourced, computed, and verified.