Moxifloxacin and Clozapine Interaction
Drug interaction information between Moxifloxacin and Clozapine.
Moxifloxacin and Clozapine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Moxifloxacin and Clozapine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Both of these medications can affect the electrical rhythm of your heart, which may increase the risk of a serious heart problem.
FDA Label Information
Drugs that cause QT prolongation include: specific antipsychotics (e.g., ziprasidone, iloperidone, chlorpromazine, thioridazine, mesoridazine, droperidol, and pimozide), specific antibiotics (e.g., erythromycin, gatifloxacin, moxifloxacin, sparfloxacin), Class 1A antiarrhythmics (e.g., quinidine, procainamide) or Class III antiarrhythmics (e.g., amiodarone, sotalol), and others (e.g., pentamidine, levomethadyl acetate, methadone, halofantrine, mefloquine, dolasetron mesylate, probucol or tacrolimus) [see Warnings and Precautions (5.9) ] .
Moxifloxacin Also Interacts With
- Lefamulin moderate
- Warfarin minor
- Sotalol minor
- Sucralfate minor
- Zinc Sulfate minor
Clozapine Also Interacts With
- Cyclobenzaprine moderate
- Diphenhydramine moderate
- Fluoxetine moderate
- Sertraline minor
- Escitalopram minor
Frequently Asked Questions
What SPL severity band is on file for Moxifloxacin + Clozapine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Clozapine has 42 labeled pairs on file vs Moxifloxacin's 10. In the minor band specifically: Moxifloxacin has 9 (also Warfarin, Sotalol, Sucralfate, Zinc Sulfate); Clozapine has 39 (also Sertraline, Escitalopram, Bupropion, Duloxetine).
What mechanism field is on file for Moxifloxacin and Clozapine?
Both of these medications can affect the electrical rhythm of your heart, which may increase the risk of a serious heart problem.
Clozapine's labeled portfolio outnumbers Moxifloxacin
SPL source-record counts only. This page's band is minor · classes on file: Moxifloxacin (Fluoroquinolone Antibiotic); Clozapine (Atypical Antipsychotic).
0 major · 1 moderate · 9 minor · 10 total
- Other minor peers for Moxifloxacin
- Warfarin
- Sotalol
- Sucralfate
- Zinc Sulfate
0 major · 3 moderate · 39 minor · 42 total
- Other minor peers for Clozapine
- Sertraline
- Escitalopram
- Bupropion
- Duloxetine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.