Moxifloxacin and Clozapine Interaction
Drug interaction information between Moxifloxacin and Clozapine.
Moxifloxacin and Clozapine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Moxifloxacin and Clozapine. Major interactions are generally avoided, moderate ones may need monitoring or a dose adjustment, and minor ones are usually low-risk. This page shows the documented mechanism and guidance. Label-documented interactions are not a complete safety review, so always confirm your own medications with a pharmacist or doctor. Educational information, not medical advice.
How They Interact
Both of these medications can affect the electrical rhythm of your heart, which may increase the risk of a serious heart problem.
What To Do
Your doctor should monitor your heart rhythm closely if you must take both of these medications at the same time.
FDA Label Information
Drugs that cause QT prolongation include: specific antipsychotics (e.g., ziprasidone, iloperidone, chlorpromazine, thioridazine, mesoridazine, droperidol, and pimozide), specific antibiotics (e.g., erythromycin, gatifloxacin, moxifloxacin, sparfloxacin), Class 1A antiarrhythmics (e.g., quinidine, procainamide) or Class III antiarrhythmics (e.g., amiodarone, sotalol), and others (e.g., pentamidine, levomethadyl acetate, methadone, halofantrine, mefloquine, dolasetron mesylate, probucol or tacrolimus) [see Warnings and Precautions (5.9) ] .
Moxifloxacin Also Interacts With
- Lefamulin moderate
- Warfarin minor
- Sotalol minor
- Sucralfate minor
- Zinc Sulfate minor
Clozapine Also Interacts With
- Cyclobenzaprine moderate
- Diphenhydramine moderate
- Fluoxetine moderate
- Sertraline minor
- Escitalopram minor
Frequently Asked Questions
Can I take Moxifloxacin and Clozapine together?
This is a minor interaction. Your doctor should monitor your heart rhythm closely if you must take both of these medications at the same time.
How serious is the interaction between Moxifloxacin and Clozapine?
This interaction is classified as "minor" severity by the FDA. Minor interactions are unlikely to cause significant problems but should still be mentioned to your healthcare provider.
Why do Moxifloxacin and Clozapine interact?
Both of these medications can affect the electrical rhythm of your heart, which may increase the risk of a serious heart problem.
Understanding the Moxifloxacin and Clozapine Interaction
FDA-approved prescribing information for these two drugs flags their combination as a minor-severity interaction. Moxifloxacin belongs to the Fluoroquinolone Antibiotic class and Clozapine belongs to the Atypical Antipsychotic class - two categories that can collide when co-prescribed. The mechanism described in FDA labeling is: Both of these medications can affect the electrical rhythm of your heart, which may increase the risk of a serious heart problem. Severity tiers matter: major flags generally advise avoidance, moderate flags often require monitoring or dose adjustment, and minor flags may only call for awareness.
Context around a specific patient determines real-world impact. Moxifloxacin has 10 total documented interactions on file in this dataset, and Clozapine has 42. Each additional medication compounds the interaction surface, which is why pharmacists run full-profile checks rather than evaluating one pair at a time. FDA-derived guidance for this pair is: Your doctor should monitor your heart rhythm closely if you must take both of these medications at the same time. Timing of doses, renal and hepatic function, age, and other concurrent prescriptions all shape whether a labeled interaction matters clinically.
An interaction flag is not a verdict. A large share of labeled interactions are managed routinely in clinical practice, the fix may be as simple as spacing doses or adding a monitoring test. Others require the prescriber to choose a different medication entirely. This page surfaces FDA-sourced labeling and openFDA data for educational purposes only; it is not medical advice and cannot account for your full clinical picture. Never start, stop, or adjust either Moxifloxacin or Clozapine based on a web page, speak with your prescriber or pharmacist before making any change.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. Always consult your healthcare provider about drug interactions.
Read our methodology - how this data is sourced, computed, and verified.