Rifampin and Glecaprevir/Pibrentasvir Interaction
Drug interaction information between Rifampin and Glecaprevir/Pibrentasvir.
Rifampin and Glecaprevir/Pibrentasvir have a documented major interaction in FDA labeling.
FDA drug labeling documents a major-severity interaction between Rifampin and Glecaprevir/Pibrentasvir. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Rifampin lowers the levels of the hepatitis C medicine in your body. This makes the treatment less effective and may prevent it from curing the infection.
FDA Label Information
Antimycobacterials: Rifampin ↓ glecaprevir ↓ pibrentasvir Coadministration is contraindicated because of potential loss of therapeutic effect [see Contraindications ( 4 ) ] .
Rifampin Also Interacts With
- Darunavir major
- Bictegravir/Emtricitabine/Tenofovir major
- Nirmatrelvir/Ritonavir major
- Pitavastatin major
- Ranolazine major
Glecaprevir/Pibrentasvir Also Interacts With
- Rosuvastatin major
- Rosuvastatin/Ezetimibe major
- Cyclosporine moderate
- Darunavir moderate
- Estradiol moderate
Frequently Asked Questions
What SPL severity band is on file for Rifampin + Glecaprevir/Pibrentasvir?
Compiled FDA labeling labels this pair major. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Rifampin has 137 labeled pairs on file vs Glecaprevir/Pibrentasvir's 38. In the major band specifically: Rifampin has 8 (also Darunavir, Bictegravir, Nirmatrelvir/Ritonavir, Pitavastatin); Glecaprevir/Pibrentasvir has 3 (also Rosuvastatin, Rosuvastatin/Ezetimibe).
What mechanism field is on file for Rifampin and Glecaprevir/Pibrentasvir?
Rifampin lowers the levels of the hepatitis C medicine in your body. This makes the treatment less effective and may prevent it from curing the infection.
Rifampin carries more major-labeled pairs than Glecaprevir/Pibrentasvir
SPL source-record counts only. This page's band is major · classes on file: Rifampin (Rifamycin Antibiotic); Glecaprevir/Pibrentasvir (NS3/4A/NS5A Inhibitor (HCV)).
Rifampin has 8 major-labeled pairs vs Glecaprevir/Pibrentasvir's 3.
8 major · 26 moderate · 103 minor · 137 total
- Other major peers for Rifampin
- Darunavir
- Bictegravir
- Nirmatrelvir/Ritonavir
- Pitavastatin
3 major · 9 moderate · 26 minor · 38 total
- Other major peers for Glecaprevir/Pibrentasvir
- Rosuvastatin
- Rosuvastatin/Ezetimibe
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.