Rifampin and Darunavir Interaction
Drug interaction information between Rifampin and Darunavir.
Rifampin and Darunavir have a documented major interaction in FDA labeling.
FDA drug labeling documents a major-severity interaction between Rifampin and Darunavir. Major interactions are generally avoided, moderate ones may need monitoring or a dose adjustment, and minor ones are usually low-risk. This page shows the documented mechanism and guidance. Label-documented interactions are not a complete safety review, so always confirm your own medications with a pharmacist or doctor. Educational information, not medical advice.
How They Interact
Rifampin reduces the amount of darunavir in your body, which can prevent the medicine from controlling the virus.
What To Do
This combination is not allowed and should be avoided.
Rifampin Also Interacts With
- Bictegravir/Emtricitabine/Tenofovir major
- Glecaprevir/Pibrentasvir major
- Nirmatrelvir/Ritonavir major
- Pitavastatin major
- Ranolazine major
Darunavir Also Interacts With
- Lovastatin major
- Sildenafil major
- Lurasidone major
- Pimozide major
- Midazolam major
Frequently Asked Questions
Can I take Rifampin and Darunavir together?
This is a major interaction. This combination is not allowed and should be avoided.
How serious is the interaction between Rifampin and Darunavir?
This interaction is classified as "major" severity by the FDA. Major interactions may be life-threatening or cause serious side effects.
Why do Rifampin and Darunavir interact?
Rifampin reduces the amount of darunavir in your body, which can prevent the medicine from controlling the virus.
Understanding the Rifampin and Darunavir Interaction
FDA-approved prescribing information for these two drugs flags their combination as a major-severity interaction. Rifampin belongs to the Rifamycin Antibiotic class and Darunavir belongs to the HIV Protease Inhibitor class - two categories that can collide when co-prescribed. The mechanism described in FDA labeling is: Rifampin reduces the amount of darunavir in your body, which can prevent the medicine from controlling the virus. Severity tiers matter: major flags generally advise avoidance, moderate flags often require monitoring or dose adjustment, and minor flags may only call for awareness.
Context around a specific patient determines real-world impact. Rifampin has 137 total documented interactions on file in this dataset, and Darunavir has 101. Each additional medication compounds the interaction surface, which is why pharmacists run full-profile checks rather than evaluating one pair at a time. FDA-derived guidance for this pair is: This combination is not allowed and should be avoided. Timing of doses, renal and hepatic function, age, and other concurrent prescriptions all shape whether a labeled interaction matters clinically.
An interaction flag is not a verdict. A large share of labeled interactions are managed routinely in clinical practice, the fix may be as simple as spacing doses or adding a monitoring test. Others require the prescriber to choose a different medication entirely. This page surfaces FDA-sourced labeling and openFDA data for educational purposes only; it is not medical advice and cannot account for your full clinical picture. Never start, stop, or adjust either Rifampin or Darunavir based on a web page, speak with your prescriber or pharmacist before making any change.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. Always consult your healthcare provider about drug interactions.
Read our methodology - how this data is sourced, computed, and verified.