Rifampin and Darunavir Interaction
Drug interaction information between Rifampin and Darunavir.
Rifampin and Darunavir have a documented major interaction in FDA labeling.
FDA drug labeling documents a major-severity interaction between Rifampin and Darunavir. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Rifampin reduces the amount of darunavir in your body, which can prevent the medicine from controlling the virus.
Rifampin Also Interacts With
- Bictegravir/Emtricitabine/Tenofovir major
- Glecaprevir/Pibrentasvir major
- Nirmatrelvir/Ritonavir major
- Pitavastatin major
- Ranolazine major
Darunavir Also Interacts With
- Lovastatin major
- Sildenafil major
- Lurasidone major
- Pimozide major
- Midazolam major
Frequently Asked Questions
What SPL severity band is on file for Rifampin + Darunavir?
Compiled FDA labeling labels this pair major. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Rifampin has 137 labeled pairs on file vs Darunavir's 101. In the major band specifically: Rifampin has 8 (also Bictegravir, Glecaprevir/Pibrentasvir, Nirmatrelvir/Ritonavir, Pitavastatin); Darunavir has 15 (also Lovastatin, Sildenafil, Lurasidone, Pimozide).
What mechanism field is on file for Rifampin and Darunavir?
Rifampin reduces the amount of darunavir in your body, which can prevent the medicine from controlling the virus.
Darunavir carries more major-labeled pairs than Rifampin
SPL source-record counts only. This page's band is major · classes on file: Rifampin (Rifamycin Antibiotic); Darunavir (HIV Protease Inhibitor).
Darunavir has 15 major-labeled pairs vs Rifampin's 8.
8 major · 26 moderate · 103 minor · 137 total
- Other major peers for Rifampin
- Bictegravir
- Glecaprevir/Pibrentasvir
- Nirmatrelvir/Ritonavir
- Pitavastatin
15 major · 16 moderate · 70 minor · 101 total
- Other major peers for Darunavir
- Lovastatin
- Sildenafil
- Lurasidone
- Pimozide
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.