Rifampin and Glipizide Interaction
Drug interaction information between Rifampin and Glipizide.
Rifampin and Glipizide have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Rifampin and Glipizide. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Rifampin speeds up the liver's ability to break down glipizide, which lowers the amount of medicine in your blood.
FDA Label Information
Glipizide Decrease exposure Immunosuppressive Agents Cyclosporine Decrease exposure Tacrolimus Prevention or Management: Monitoring of whole blood concentrations and appropriate dosage adjustments of tacrolimus are recommended when rifampin and tacrolimus are used concomitantly.
Rifampin Also Interacts With
- Darunavir major
- Bictegravir/Emtricitabine/Tenofovir major
- Glecaprevir/Pibrentasvir major
- Nirmatrelvir/Ritonavir major
- Pitavastatin major
Glipizide Also Interacts With
- Fluconazole minor
- Colesevelam minor
- Probenecid minor
- Phenytoin minor
- Lovastatin minor
Frequently Asked Questions
What SPL severity band is on file for Rifampin + Glipizide?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Rifampin has 137 labeled pairs on file vs Glipizide's 8. In the minor band specifically: Rifampin has 103 (also Metoprolol, Losartan, Simvastatin, Propranolol); Glipizide has 8 (also Fluconazole, Colesevelam, Probenecid, Phenytoin).
What mechanism field is on file for Rifampin and Glipizide?
Rifampin speeds up the liver's ability to break down glipizide, which lowers the amount of medicine in your blood.
Rifampin carries more major-labeled pairs than Glipizide
SPL source-record counts only. This page's band is minor · classes on file: Rifampin (Rifamycin Antibiotic); Glipizide (Sulfonylurea).
Rifampin has 8 major-labeled pairs vs Glipizide's 0. This page itself is in the minor band, not the major band.
8 major · 26 moderate · 103 minor · 137 total
- Other minor peers for Rifampin
- Metoprolol
- Losartan
- Simvastatin
- Propranolol
0 major · 0 moderate · 8 minor · 8 total
- Other minor peers for Glipizide
- Fluconazole
- Colesevelam
- Probenecid
- Phenytoin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.