What the FDA labels say about taking them together
Losartan and rifampin
Losartan's FDA label of January 20, 2026 names rifampin in its drug interactions section; the rifampin label PlainMeds reads does not name losartan. The losartan label: “However, rifampin has been shown to decrease the AUC of losartan and its active metabolite by 30% and 40%, respectively.”
Check it at the source: the losartan FDA label on DailyMed (effective January 20, 2026, Organon LLC); the rifampin FDA label on DailyMed (effective February 11, 2026, Lupin Pharmaceuticals, Inc.).
What does the losartan label say about rifampin?
Losartan label, drug interactionsHowever, rifampin has been shown to decrease the AUC of losartan and its active metabolite by 30% and 40%, respectively.
Source: FDA drug label (COZAAR), Organon LLC, effective January 20, 2026 (SPL set 9949448f-c3b9-44ee-94ed-c1aca8c90f39), via openFDA; the full label on DailyMed
What does the rifampin label say about losartan?
Rifampin's label (effective February 11, 2026) does not name losartan in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (rifampin), Lupin Pharmaceuticals, Inc., effective February 11, 2026 (SPL set b56004f0-f23d-47f6-80c7-39884fccbccc), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Losartan | Rifampin | |
|---|---|---|
| Labeled for | High blood pressure, Chronic kidney disease, Stroke prevention | n/a |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $0.0327 per tablet 50 mg tablet | $0.679 per capsule 300 mg capsule |
| Shortage now | No current entry | In shortage |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once