Nitrofurantoin and Dapsone Topical Interaction
Drug interaction information between Nitrofurantoin and Dapsone Topical.
Nitrofurantoin and Dapsone Topical have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Nitrofurantoin and Dapsone Topical. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
These medications both have the potential to change how your blood carries oxygen. Using them at the same time makes it more likely you will develop a blood problem called methemoglobinemia.
FDA Label Information
7.4 Concomitant Use with Drugs that Induce Methemoglobinemia Concomitant use of ACZONE Gel, 7.5% with drugs that induce methemoglobinemia such as sulfonamides, acetaminophen, acetanilide, aniline dyes, benzocaine, chloroquine, dapsone, naphthalene, nitrates and nitrites, nitrofurantoin, nitroglycerin, nitroprusside, pamaquine, para‐aminosalicylic acid, phenacetin, phenobarbital, phenytoin, primaquine, and quinine may increase the risk for developing methemoglobinemia [see Warnings and Precautions ( 5.1 )] .
Nitrofurantoin Also Interacts With
- Lidocaine Topical moderate
- Probenecid minor
- Methylprednisolone minor
Dapsone Topical Also Interacts With
- Acetaminophen moderate
- Chloroquine moderate
- Nitroglycerin moderate
- Phenytoin moderate
- Phenobarbital moderate
Frequently Asked Questions
What SPL severity band is on file for Nitrofurantoin + Dapsone Topical?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Dapsone Topical has 10 labeled pairs on file vs Nitrofurantoin's 4. In the moderate band specifically: Nitrofurantoin has 2 (also Lidocaine Topical); Dapsone Topical has 6 (also Acetaminophen, Chloroquine, Nitroglycerin, Phenytoin).
What mechanism field is on file for Nitrofurantoin and Dapsone Topical?
These medications both have the potential to change how your blood carries oxygen. Using them at the same time makes it more likely you will develop a blood problem called methemoglobinemia.
Dapsone Topical's labeled portfolio outnumbers Nitrofurantoin
SPL source-record counts only. This page's band is moderate · classes on file: Nitrofurantoin (Nitrofuran Antibiotic); Dapsone Topical (Topical Anti-Inflammatory).
0 major · 2 moderate · 2 minor · 4 total
- Other moderate peers for Nitrofurantoin
- Lidocaine Topical
0 major · 6 moderate · 4 minor · 10 total
- Other moderate peers for Dapsone Topical
- Acetaminophen
- Chloroquine
- Nitroglycerin
- Phenytoin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.