Nitrofurantoin and Lidocaine Topical Interaction
Drug interaction information between Nitrofurantoin and Lidocaine Topical.
Nitrofurantoin and Lidocaine Topical have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Nitrofurantoin and Lidocaine Topical. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Both drugs can cause a blood problem that makes it hard for your body to get enough oxygen. Using them together increases the risk of this serious condition.
FDA Label Information
Drugs That May Cause Methemoglobinemia When Used with LIDODERM Patients who are administered local anesthetics are at increased risk of developing methemoglobinemia when concurrently exposed to the following drugs, which could include other local anesthetics: Examples of Drugs Associated with Methemoglobinemia : Class Examples Nitrates/Nitrites nitric oxide, nitroglycerin, nitroprusside, nitrous oxide Local anesthetics articaine, benzocaine, bupivacaine, lidocaine, mepivacaine, prilocaine, procaine, ropivacaine, tetracaine Antineoplastic agents cyclophosphamide, flutamide, hydroxyurea,...
Nitrofurantoin Also Interacts With
- Dapsone Topical moderate
- Probenecid minor
- Methylprednisolone minor
Lidocaine Topical Also Interacts With
- Acetaminophen moderate
- Valproate moderate
- Chloroquine moderate
- Mexiletine moderate
- Nitroglycerin moderate
Frequently Asked Questions
What SPL severity band is on file for Nitrofurantoin + Lidocaine Topical?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Lidocaine Topical has 10 labeled pairs on file vs Nitrofurantoin's 4. In the moderate band specifically: Nitrofurantoin has 2 (also Dapsone Topical); Lidocaine Topical has 10 (also Acetaminophen, Valproate, Chloroquine, Mexiletine).
What mechanism field is on file for Nitrofurantoin and Lidocaine Topical?
Both drugs can cause a blood problem that makes it hard for your body to get enough oxygen. Using them together increases the risk of this serious condition.
Lidocaine Topical's labeled portfolio outnumbers Nitrofurantoin
SPL source-record counts only. This page's band is moderate · classes on file: Nitrofurantoin (Nitrofuran Antibiotic); Lidocaine Topical (Topical Anesthetic).
0 major · 2 moderate · 2 minor · 4 total
- Other moderate peers for Nitrofurantoin
- Dapsone Topical
0 major · 10 moderate · 0 minor · 10 total
- Other moderate peers for Lidocaine Topical
- Acetaminophen
- Valproate
- Chloroquine
- Mexiletine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.