What the FDA labels say about taking them together
Nitrofurantoin and probenecid
Nitrofurantoin's FDA label of June 24, 2026 names probenecid in its drug interactions section; the probenecid label PlainMeds reads does not name nitrofurantoin.
Check it at the source: the nitrofurantoin FDA label on DailyMed (effective June 24, 2026); the probenecid FDA label on DailyMed (effective January 5, 2021, Lannett Company, Inc.).
What does the nitrofurantoin label say about probenecid?
Nitrofurantoin label, drug interactionsUricosuric drugs, such as probenecid and sulfinpyrazone, can inhibit renal tubular secretion of nitrofurantoin.
Source: FDA drug label (Nitrofurantoin Monohydrate/ Macrocrystalline), REMEDYREPACK INC., effective June 24, 2026 (SPL set a4afd48b-003f-4ffa-9ca0-9432b8b0e22b), via openFDA; the full label on DailyMed
What does the probenecid label say about nitrofurantoin?
Probenecid's label (effective January 5, 2021) does not name nitrofurantoin in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Probenecid), Lannett Company, Inc., effective January 5, 2021 (SPL set ab497fd8-00c3-4364-b003-b39d21fbdf38), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Nitrofurantoin | Probenecid | |
|---|---|---|
| Labeled for | Urinary tract infections, Bacterial infections | Gout |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.165 per capsule 50 mg capsule | $0.636 per tablet 500 mg tablet |
| Shortage now | A presentation being discontinued | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once