Nitrofurantoin and Probenecid Interaction
Drug interaction information between Nitrofurantoin and Probenecid.
Nitrofurantoin and Probenecid have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Nitrofurantoin and Probenecid. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Probenecid stops the kidneys from moving nitrofurantoin into the urine, which can make the antibiotic less effective for treating a bladder infection.
FDA Label Information
7.2 Uricosuric Drugs Uricosuric drugs, such as probenecid and sulfinpyrazone, can inhibit renal tubular secretion of nitrofurantoin.
Nitrofurantoin Also Interacts With
- Dapsone Topical moderate
- Lidocaine Topical moderate
- Methylprednisolone minor
Probenecid Also Interacts With
- Ketorolac major
- Levofloxacin major
- Amoxicillin moderate
- Amoxicillin/Clavulanate moderate
- Ceftazidime/Avibactam moderate
Frequently Asked Questions
What SPL severity band is on file for Nitrofurantoin + Probenecid?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Probenecid has 37 labeled pairs on file vs Nitrofurantoin's 4. In the minor band specifically: Nitrofurantoin has 2 (also Methylprednisolone); Probenecid has 23 (also Theophylline, Acetaminophen/Oxycodone, Ampicillin/Sulbactam, Carbidopa/Levodopa).
What mechanism field is on file for Nitrofurantoin and Probenecid?
Probenecid stops the kidneys from moving nitrofurantoin into the urine, which can make the antibiotic less effective for treating a bladder infection.
Probenecid carries more major-labeled pairs than Nitrofurantoin
SPL source-record counts only. This page's band is minor · classes on file: Nitrofurantoin (Nitrofuran Antibiotic); Probenecid (Uricosuric Agent).
Probenecid has 2 major-labeled pairs vs Nitrofurantoin's 0. This page itself is in the minor band, not the major band.
0 major · 2 moderate · 2 minor · 4 total
- Other minor peers for Nitrofurantoin
- Methylprednisolone
2 major · 12 moderate · 23 minor · 37 total
- Other minor peers for Probenecid
- Theophylline
- Acetaminophen/Oxycodone
- Ampicillin/Sulbactam
- Carbidopa/Levodopa
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.