Methylprednisolone and Darunavir Interaction
Drug interaction information between Methylprednisolone and Darunavir.
Methylprednisolone and Darunavir have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Methylprednisolone and Darunavir. Major interactions are generally avoided, moderate ones may need monitoring or a dose adjustment, and minor ones are usually low-risk. This page shows the documented mechanism and guidance. Label-documented interactions are not a complete safety review, so always confirm your own medications with a pharmacist or doctor. Educational information, not medical advice.
How They Interact
Darunavir stops the body from breaking down methylprednisolone, which causes the steroid to build up to high levels. This can lead to serious hormone problems like Cushing's syndrome.
What To Do
Your doctor may need to adjust your dose or monitor you closely for signs of too much steroid in your system.
FDA Label Information
betamethasone budesonide ciclesonide fluticasone methylprednisolone mometasone triamcinolone ↑ corticosteroids Co-administration with corticosteroids (all routes of administration) of which exposures are significantly increased by strong CYP3A inhibitors can increase the risk for Cushing's syndrome and adrenal suppression.
Methylprednisolone Also Interacts With
- Theophylline major
- Aspirin moderate
- Ketoconazole moderate
- Aprepitant moderate
- Clarithromycin moderate
Darunavir Also Interacts With
- Lovastatin major
- Sildenafil major
- Lurasidone major
- Pimozide major
- Midazolam major
Frequently Asked Questions
Can I take Methylprednisolone and Darunavir together?
This is a moderate interaction. Your doctor may need to adjust your dose or monitor you closely for signs of too much steroid in your system.
How serious is the interaction between Methylprednisolone and Darunavir?
This interaction is classified as "moderate" severity by the FDA. Moderate interactions may worsen your condition or change how your medications work.
Why do Methylprednisolone and Darunavir interact?
Darunavir stops the body from breaking down methylprednisolone, which causes the steroid to build up to high levels. This can lead to serious hormone problems like Cushing's syndrome.
Understanding the Methylprednisolone and Darunavir Interaction
FDA-approved prescribing information for these two drugs flags their combination as a moderate-severity interaction. Methylprednisolone belongs to the Corticosteroid class and Darunavir belongs to the HIV Protease Inhibitor class - two categories that can collide when co-prescribed. The mechanism described in FDA labeling is: Darunavir stops the body from breaking down methylprednisolone, which causes the steroid to build up to high levels. Severity tiers matter: major flags generally advise avoidance, moderate flags often require monitoring or dose adjustment, and minor flags may only call for awareness.
Context around a specific patient determines real-world impact. Methylprednisolone has 29 total documented interactions on file in this dataset, and Darunavir has 101. Each additional medication compounds the interaction surface, which is why pharmacists run full-profile checks rather than evaluating one pair at a time. FDA-derived guidance for this pair is: Your doctor may need to adjust your dose or monitor you closely for signs of too much steroid in your system. Timing of doses, renal and hepatic function, age, and other concurrent prescriptions all shape whether a labeled interaction matters clinically.
An interaction flag is not a verdict. A large share of labeled interactions are managed routinely in clinical practice, the fix may be as simple as spacing doses or adding a monitoring test. Others require the prescriber to choose a different medication entirely. This page surfaces FDA-sourced labeling and openFDA data for educational purposes only; it is not medical advice and cannot account for your full clinical picture. Never start, stop, or adjust either Methylprednisolone or Darunavir based on a web page, speak with your prescriber or pharmacist before making any change.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. Always consult your healthcare provider about drug interactions.
Read our methodology - how this data is sourced, computed, and verified.