Medroxyprogesterone and Carbamazepine Interaction
Drug interaction information between Medroxyprogesterone and Carbamazepine.
Medroxyprogesterone and Carbamazepine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Medroxyprogesterone and Carbamazepine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Carbamazepine can make medroxyprogesterone less effective at preventing pregnancy.
FDA Label Information
Some drugs or herbal products that may decrease the effectiveness of hormonal contraceptives include: barbiturates bosentan carbamazepine felbamate griseofulvin oxcarbazepine phenytoin rifampin St.
Medroxyprogesterone Also Interacts With
- Theophylline major
- Estradiol minor
- Topiramate minor
- Progesterone minor
- Testosterone minor
Carbamazepine Also Interacts With
- Nirmatrelvir/Ritonavir major
- Ranolazine major
- Risperidone major
- Lithium moderate
- Apixaban moderate
Frequently Asked Questions
What SPL severity band is on file for Medroxyprogesterone + Carbamazepine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Carbamazepine has 129 labeled pairs on file vs Medroxyprogesterone's 11. In the minor band specifically: Medroxyprogesterone has 10 (also Estradiol, Topiramate, Progesterone, Testosterone); Carbamazepine has 110 (also Omeprazole, Ibuprofen, Citalopram, Amitriptyline).
What mechanism field is on file for Medroxyprogesterone and Carbamazepine?
Carbamazepine can make medroxyprogesterone less effective at preventing pregnancy.
Carbamazepine carries more major-labeled pairs than Medroxyprogesterone
SPL source-record counts only. This page's band is minor · classes on file: Medroxyprogesterone (Progestogen); Carbamazepine (Anticonvulsant).
Carbamazepine has 3 major-labeled pairs vs Medroxyprogesterone's 1. This page itself is in the minor band, not the major band.
1 major · 0 moderate · 10 minor · 11 total
- Other minor peers for Medroxyprogesterone
- Estradiol
- Topiramate
- Progesterone
- Testosterone
3 major · 16 moderate · 110 minor · 129 total
- Other minor peers for Carbamazepine
- Omeprazole
- Ibuprofen
- Citalopram
- Amitriptyline
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.