Medroxyprogesterone and Carbamazepine Interaction
Drug interaction information between Medroxyprogesterone and Carbamazepine.
Medroxyprogesterone and Carbamazepine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Medroxyprogesterone and Carbamazepine. Major interactions are generally avoided, moderate ones may need monitoring or a dose adjustment, and minor ones are usually low-risk. This page shows the documented mechanism and guidance. Label-documented interactions are not a complete safety review, so always confirm your own medications with a pharmacist or doctor. Educational information, not medical advice.
How They Interact
Carbamazepine can make medroxyprogesterone less effective at preventing pregnancy.
What To Do
You should use an extra form of birth control while taking these medications together.
FDA Label Information
Some drugs or herbal products that may decrease the effectiveness of hormonal contraceptives include: barbiturates bosentan carbamazepine felbamate griseofulvin oxcarbazepine phenytoin rifampin St.
Medroxyprogesterone Also Interacts With
- Theophylline major
- Estradiol minor
- Topiramate minor
- Progesterone minor
- Testosterone minor
Carbamazepine Also Interacts With
- Nirmatrelvir/Ritonavir major
- Ranolazine major
- Risperidone major
- Lithium moderate
- Apixaban moderate
Frequently Asked Questions
Can I take Medroxyprogesterone and Carbamazepine together?
This is a minor interaction. You should use an extra form of birth control while taking these medications together.
How serious is the interaction between Medroxyprogesterone and Carbamazepine?
This interaction is classified as "minor" severity by the FDA. Minor interactions are unlikely to cause significant problems but should still be mentioned to your healthcare provider.
Why do Medroxyprogesterone and Carbamazepine interact?
Carbamazepine can make medroxyprogesterone less effective at preventing pregnancy.
Understanding the Medroxyprogesterone and Carbamazepine Interaction
FDA-approved prescribing information for these two drugs flags their combination as a minor-severity interaction. Medroxyprogesterone belongs to the Progestogen class and Carbamazepine belongs to the Anticonvulsant class - two categories that can collide when co-prescribed. The mechanism described in FDA labeling is: Carbamazepine can make medroxyprogesterone less effective at preventing pregnancy. Severity tiers matter: major flags generally advise avoidance, moderate flags often require monitoring or dose adjustment, and minor flags may only call for awareness.
Context around a specific patient determines real-world impact. Medroxyprogesterone has 11 total documented interactions on file in this dataset, and Carbamazepine has 129. Each additional medication compounds the interaction surface, which is why pharmacists run full-profile checks rather than evaluating one pair at a time. FDA-derived guidance for this pair is: You should use an extra form of birth control while taking these medications together. Timing of doses, renal and hepatic function, age, and other concurrent prescriptions all shape whether a labeled interaction matters clinically.
An interaction flag is not a verdict. A large share of labeled interactions are managed routinely in clinical practice, the fix may be as simple as spacing doses or adding a monitoring test. Others require the prescriber to choose a different medication entirely. This page surfaces FDA-sourced labeling and openFDA data for educational purposes only; it is not medical advice and cannot account for your full clinical picture. Never start, stop, or adjust either Medroxyprogesterone or Carbamazepine based on a web page, speak with your prescriber or pharmacist before making any change.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. Always consult your healthcare provider about drug interactions.
Read our methodology - how this data is sourced, computed, and verified.