Medroxyprogesterone and Estradiol Interaction
Drug interaction information between Medroxyprogesterone and Estradiol.
Medroxyprogesterone and Estradiol have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Medroxyprogesterone and Estradiol. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Medroxyprogesterone can lower the amount of estradiol found in your blood and urine.
FDA Label Information
The following laboratory tests may be affected by progestins including medroxyprogesterone acetate injectable suspension: (a) Plasma and urinary steroid levels are decreased (e.g., progesterone, estradiol, pregnanediol, testosterone, cortisol).
Medroxyprogesterone Also Interacts With
- Theophylline major
- Topiramate minor
- Progesterone minor
- Testosterone minor
- Carbamazepine minor
Estradiol Also Interacts With
- Drospirenone/Ethinyl Estradiol major
- Glecaprevir/Pibrentasvir moderate
- Etonogestrel moderate
- Tacrolimus Topical moderate
- Rosuvastatin minor
Frequently Asked Questions
What SPL severity band is on file for Medroxyprogesterone + Estradiol?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Estradiol has 54 labeled pairs on file vs Medroxyprogesterone's 11. In the minor band specifically: Medroxyprogesterone has 10 (also Topiramate, Progesterone, Testosterone, Carbamazepine); Estradiol has 50 (also Rosuvastatin, Lamotrigine, Topiramate, Tizanidine).
What mechanism field is on file for Medroxyprogesterone and Estradiol?
Medroxyprogesterone can lower the amount of estradiol found in your blood and urine.
Estradiol's labeled portfolio outnumbers Medroxyprogesterone
SPL source-record counts only. This page's band is minor · classes on file: Medroxyprogesterone (Progestogen); Estradiol (Estrogen Hormone).
1 major · 0 moderate · 10 minor · 11 total
- Other minor peers for Medroxyprogesterone
- Topiramate
- Progesterone
- Testosterone
- Carbamazepine
1 major · 3 moderate · 50 minor · 54 total
- Other minor peers for Estradiol
- Rosuvastatin
- Lamotrigine
- Topiramate
- Tizanidine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.