Medroxyprogesterone and Progesterone Interaction
Drug interaction information between Medroxyprogesterone and Progesterone.
Medroxyprogesterone and Progesterone have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Medroxyprogesterone and Progesterone. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Medroxyprogesterone can reduce the levels of progesterone measured in your body.
FDA Label Information
Counsel patients to use a back-up method or alternative method of contraception when enzyme inducers are used with medroxyprogesterone acetate injectable suspension. The following laboratory tests may be affected by progestins including medroxyprogesterone acetate injectable suspension: (a) Plasma and urinary steroid levels are decreased (e.g., progesterone, estradiol, pregnanediol, testosterone, cortisol). (g) The effects of medroxyprogesterone acetate on lipid metabolism are inconsistent.
Medroxyprogesterone Also Interacts With
- Theophylline major
- Estradiol minor
- Topiramate minor
- Testosterone minor
- Carbamazepine minor
Progesterone Also Interacts With
- Isotretinoin major
- Theophylline major
- Amoxicillin minor
- Amoxicillin/Clavulanate minor
- Phenobarbital minor
Frequently Asked Questions
What SPL severity band is on file for Medroxyprogesterone + Progesterone?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Medroxyprogesterone has 11 labeled pairs on file vs Progesterone's 7. In the minor band specifically: Medroxyprogesterone has 10 (also Estradiol, Topiramate, Testosterone, Carbamazepine); Progesterone has 5 (also Amoxicillin, Amoxicillin/Clavulanate, Phenobarbital, Ziprasidone).
What mechanism field is on file for Medroxyprogesterone and Progesterone?
Medroxyprogesterone can reduce the levels of progesterone measured in your body.
Progesterone carries more major-labeled pairs than Medroxyprogesterone
SPL source-record counts only. This page's band is minor · classes on file: Medroxyprogesterone (Progestogen); Progesterone (Progestogen Hormone).
Progesterone has 2 major-labeled pairs vs Medroxyprogesterone's 1. This page itself is in the minor band, not the major band.
1 major · 0 moderate · 10 minor · 11 total
- Other minor peers for Medroxyprogesterone
- Estradiol
- Topiramate
- Testosterone
- Carbamazepine
2 major · 0 moderate · 5 minor · 7 total
- Other minor peers for Progesterone
- Amoxicillin
- Amoxicillin/Clavulanate
- Phenobarbital
- Ziprasidone
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.