Medroxyprogesterone and Testosterone Interaction
Drug interaction information between Medroxyprogesterone and Testosterone.
Medroxyprogesterone and Testosterone have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Medroxyprogesterone and Testosterone. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Medroxyprogesterone can lower the amount of testosterone found in your blood and urine.
FDA Label Information
The following laboratory tests may be affected by progestins including medroxyprogesterone acetate injectable suspension: (a) Plasma and urinary steroid levels are decreased (e.g., progesterone, estradiol, pregnanediol, testosterone, cortisol).
Medroxyprogesterone Also Interacts With
- Theophylline major
- Estradiol minor
- Topiramate minor
- Progesterone minor
- Carbamazepine minor
Frequently Asked Questions
What SPL severity band is on file for Medroxyprogesterone + Testosterone?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Medroxyprogesterone has 11 labeled pairs on file vs Testosterone's 2. In the minor band specifically: Medroxyprogesterone has 10 (also Estradiol, Topiramate, Progesterone, Carbamazepine); Testosterone has 2 (also Lovastatin).
What mechanism field is on file for Medroxyprogesterone and Testosterone?
Medroxyprogesterone can lower the amount of testosterone found in your blood and urine.
Medroxyprogesterone carries more major-labeled pairs than Testosterone
SPL source-record counts only. This page's band is minor · classes on file: Medroxyprogesterone (Progestogen); Testosterone (Androgen Hormone).
Medroxyprogesterone has 1 major-labeled pair vs Testosterone's 0. This page itself is in the minor band, not the major band.
1 major · 0 moderate · 10 minor · 11 total
- Other minor peers for Medroxyprogesterone
- Estradiol
- Topiramate
- Progesterone
- Carbamazepine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.