Medroxyprogesterone and Topiramate Interaction
Drug interaction information between Medroxyprogesterone and Topiramate.
Medroxyprogesterone and Topiramate have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Medroxyprogesterone and Topiramate. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Topiramate can cause the levels of medroxyprogesterone in your blood to change significantly.
FDA Label Information
John’s wort topiramate HIV protease inhibitors and non-nucleoside reverse transcriptase inhibitors : Significant changes (increase or decrease) in the plasma levels of progestin have been noted in some cases of coadministration of HIV protease inhibitors.
Medroxyprogesterone Also Interacts With
- Theophylline major
- Estradiol minor
- Progesterone minor
- Testosterone minor
- Carbamazepine minor
Topiramate Also Interacts With
- Zonisamide moderate
- Alogliptin moderate
- Ertugliflozin moderate
- Hydrochlorothiazide minor
- Amitriptyline minor
Frequently Asked Questions
What SPL severity band is on file for Medroxyprogesterone + Topiramate?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Topiramate has 30 labeled pairs on file vs Medroxyprogesterone's 11. In the minor band specifically: Medroxyprogesterone has 10 (also Estradiol, Progesterone, Testosterone, Carbamazepine); Topiramate has 27 (also Hydrochlorothiazide, Amitriptyline, Pioglitazone, Carbamazepine).
What mechanism field is on file for Medroxyprogesterone and Topiramate?
Topiramate can cause the levels of medroxyprogesterone in your blood to change significantly.
Medroxyprogesterone carries more major-labeled pairs than Topiramate
SPL source-record counts only. This page's band is minor · classes on file: Medroxyprogesterone (Progestogen); Topiramate (Anticonvulsant).
Medroxyprogesterone has 1 major-labeled pair vs Topiramate's 0. This page itself is in the minor band, not the major band.
1 major · 0 moderate · 10 minor · 11 total
- Other minor peers for Medroxyprogesterone
- Estradiol
- Progesterone
- Testosterone
- Carbamazepine
0 major · 3 moderate · 27 minor · 30 total
- Other minor peers for Topiramate
- Hydrochlorothiazide
- Amitriptyline
- Pioglitazone
- Carbamazepine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.