What the FDA labels say about taking them together
Medroxyprogesterone and topiramate
Medroxyprogesterone's FDA label (Depo-Provera) of August 25, 2026 names topiramate in its drug interactions section; the topiramate labels PlainMeds reads (4) do not name medroxyprogesterone. The medroxyprogesterone label: “topiramate HIV protease inhibitors and non-nucleoside reverse transcriptase inhibitors: Significant changes (increase or decrease) in the plasma levels of progestin have been noted in some cases of co-administration of …”
Check it at the source: the medroxyprogesterone FDA label on DailyMed (effective June 29, 2026, Pharmacia & Upjohn Company LLC); the topiramate FDA label on DailyMed (effective June 1, 2026, Sun Pharmaceutical Industries, Inc.).
What does the medroxyprogesterone label say about topiramate?
Depo-Provera label (Pharmacia & Upjohn Company LLC, August 25, 2026), drug interactionstopiramate HIV protease inhibitors and non-nucleoside reverse transcriptase inhibitors: Significant changes (increase or decrease) in the plasma levels of progestin have been noted in some cases of co-administration of HIV protease inhibitors.
Source: FDA drug label (Depo-Provera, NDA020246), Pharmacia & Upjohn Company LLC, effective August 25, 2026 (SPL set 199cf13e-0859-4a73-9b45-e700d0cd1049), via openFDA
Source: FDA drug label (Provera), NDA011839 (Pfizer), as published by Pharmacia & Upjohn Company LLC, effective June 29, 2026 (SPL set a586be28-96af-4fed-a13f-9b94fd4c7405), via openFDA; the full label on DailyMed
What does the topiramate label say about medroxyprogesterone?
Topiramate's label (effective June 1, 2026) and its 3 other brand-application labels do not name medroxyprogesterone in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Topiramate), Sun Pharmaceutical Industries, Inc., effective June 1, 2026 (SPL set 3c909a53-ae66-4b28-a741-b60bb25a69cf), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Medroxyprogesterone | Topiramate | |
|---|---|---|
| Labeled for | Birth control, Pain | Seizures and epilepsy, Migraine |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $22.85 per mL 150 mg/mL | $0.0567 per tablet 100 mg tablet |
| Shortage now | A presentation being discontinued | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once