Lisdexamfetamine and Simvastatin Interaction
Drug interaction information between Lisdexamfetamine and Simvastatin.
Lisdexamfetamine and Simvastatin have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Lisdexamfetamine and Simvastatin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Lisdexamfetamine does not interfere with the way your body processes this cholesterol medicine. Both drugs can work normally without affecting each other's levels.
FDA Label Information
From a pharmacokinetic perspective, no dose adjustment for drugs that are substrates of CYP1A2 (e.g., theophylline, duloxetine, melatonin), CYP2D6 (e.g., atomoxetine, desipramine, venlafaxine), CYP2C19 (e.g., omeprazole, lansoprazole, clobazam), and CYP3A4 (e.g., midazolam, pimozide, simvastatin) is necessary when VYVANSE is co-administered [see Clinical Pharmacology (12.3) ] .
Lisdexamfetamine Also Interacts With
- Omeprazole minor
- Duloxetine minor
- Venlafaxine minor
- Atomoxetine minor
- Melatonin minor
Simvastatin Also Interacts With
- Diltiazem major
- Verapamil major
- Cyclosporine major
- Amiodarone major
- Dronedarone major
Frequently Asked Questions
What SPL severity band is on file for Lisdexamfetamine + Simvastatin?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Simvastatin has 41 labeled pairs on file vs Lisdexamfetamine's 14. In the minor band specifically: Lisdexamfetamine has 14 (also Omeprazole, Duloxetine, Venlafaxine, Atomoxetine); Simvastatin has 21 (also Fenofibrate, Ketoconazole, Erythromycin, Clarithromycin).
What mechanism field is on file for Lisdexamfetamine and Simvastatin?
Lisdexamfetamine does not interfere with the way your body processes this cholesterol medicine. Both drugs can work normally without affecting each other's levels.
Simvastatin carries more major-labeled pairs than Lisdexamfetamine
SPL source-record counts only. This page's band is minor · classes on file: Lisdexamfetamine (CNS Stimulant); Simvastatin (HMG-CoA Reductase Inhibitor (Statin)).
Simvastatin has 11 major-labeled pairs vs Lisdexamfetamine's 0. This page itself is in the minor band, not the major band.
0 major · 0 moderate · 14 minor · 14 total
- Other minor peers for Lisdexamfetamine
- Omeprazole
- Duloxetine
- Venlafaxine
- Atomoxetine
11 major · 9 moderate · 21 minor · 41 total
- Other minor peers for Simvastatin
- Fenofibrate
- Ketoconazole
- Erythromycin
- Clarithromycin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.