Lisdexamfetamine and Atomoxetine Interaction
Drug interaction information between Lisdexamfetamine and Atomoxetine.
Lisdexamfetamine and Atomoxetine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Lisdexamfetamine and Atomoxetine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Lisdexamfetamine does not affect the specific liver enzyme that processes atomoxetine.
FDA Label Information
From a pharmacokinetic perspective, no dose adjustment for drugs that are substrates of CYP1A2 (e.g., theophylline, duloxetine, melatonin), CYP2D6 (e.g., atomoxetine, desipramine, venlafaxine), CYP2C19 (e.g., omeprazole, lansoprazole, clobazam), and CYP3A4 (e.g., midazolam, pimozide, simvastatin) is necessary when VYVANSE is co-administered [see Clinical Pharmacology (12.3) ] .
Lisdexamfetamine Also Interacts With
- Omeprazole minor
- Simvastatin minor
- Duloxetine minor
- Venlafaxine minor
- Melatonin minor
Atomoxetine Also Interacts With
- Albuterol moderate
- Omeprazole minor
- Fluoxetine minor
- Methylphenidate minor
- Warfarin minor
Frequently Asked Questions
What SPL severity band is on file for Lisdexamfetamine + Atomoxetine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Atomoxetine has 15 labeled pairs on file vs Lisdexamfetamine's 14. In the minor band specifically: Lisdexamfetamine has 14 (also Omeprazole, Simvastatin, Duloxetine, Venlafaxine); Atomoxetine has 14 (also Omeprazole, Fluoxetine, Methylphenidate, Warfarin).
What mechanism field is on file for Lisdexamfetamine and Atomoxetine?
Lisdexamfetamine does not affect the specific liver enzyme that processes atomoxetine.
Atomoxetine's labeled portfolio outnumbers Lisdexamfetamine
SPL source-record counts only. This page's band is minor · classes on file: Lisdexamfetamine (CNS Stimulant); Atomoxetine (Selective Norepinephrine Reuptake Inhibitor).
0 major · 0 moderate · 14 minor · 14 total
- Other minor peers for Lisdexamfetamine
- Omeprazole
- Simvastatin
- Duloxetine
- Venlafaxine
0 major · 1 moderate · 14 minor · 15 total
- Other minor peers for Atomoxetine
- Omeprazole
- Fluoxetine
- Methylphenidate
- Warfarin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.