Simvastatin and Fenofibrate Interaction
Drug interaction information between Simvastatin and Fenofibrate.
Simvastatin and Fenofibrate have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Simvastatin and Fenofibrate. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Taking these medicines together can cause more cholesterol to enter your bile, which increases the risk of developing gallstones.
FDA Label Information
( 7.3 ) Fenofibrates : Combination increases exposure of ezetimibe. If cholelithiasis is suspected in a patient receiving ezetimibe and a fenofibrate, gallbladder studies are indicated and alternative lipid-lowering therapy should be considered. Fenofibrates Clinical Impact: Both ezetimibe and fenofibrates may increase cholesterol excretion into the bile, leading to cholelithiasis.
Simvastatin Also Interacts With
- Diltiazem major
- Verapamil major
- Cyclosporine major
- Amiodarone major
- Dronedarone major
Fenofibrate Also Interacts With
- Cyclosporine moderate
- Colchicine moderate
- Bempedoic Acid moderate
- Bempedoic Acid/Ezetimibe moderate
- Ezetimibe minor
Frequently Asked Questions
What SPL severity band is on file for Simvastatin + Fenofibrate?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Simvastatin has 41 labeled pairs on file vs Fenofibrate's 9. In the minor band specifically: Simvastatin has 21 (also Ketoconazole, Erythromycin, Clarithromycin, Darunavir); Fenofibrate has 5 (also Ezetimibe, Ezetimibe/Simvastatin, Rosuvastatin, Rosuvastatin/Ezetimibe).
What mechanism field is on file for Simvastatin and Fenofibrate?
Taking these medicines together can cause more cholesterol to enter your bile, which increases the risk of developing gallstones.
Simvastatin carries more major-labeled pairs than Fenofibrate
SPL source-record counts only. This page's band is minor · classes on file: Simvastatin (HMG-CoA Reductase Inhibitor (Statin)); Fenofibrate (Fibrate).
Simvastatin has 11 major-labeled pairs vs Fenofibrate's 0. This page itself is in the minor band, not the major band.
11 major · 9 moderate · 21 minor · 41 total
- Other minor peers for Simvastatin
- Ketoconazole
- Erythromycin
- Clarithromycin
- Darunavir
0 major · 4 moderate · 5 minor · 9 total
- Other minor peers for Fenofibrate
- Ezetimibe
- Ezetimibe/Simvastatin
- Rosuvastatin
- Rosuvastatin/Ezetimibe
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.