Lisdexamfetamine and Duloxetine Interaction
Drug interaction information between Lisdexamfetamine and Duloxetine.
Lisdexamfetamine and Duloxetine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Lisdexamfetamine and Duloxetine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
This ADHD medicine does not change how your body breaks down this antidepressant. They do not have a significant chemical interaction in the liver.
FDA Label Information
From a pharmacokinetic perspective, no dose adjustment for drugs that are substrates of CYP1A2 (e.g., theophylline, duloxetine, melatonin), CYP2D6 (e.g., atomoxetine, desipramine, venlafaxine), CYP2C19 (e.g., omeprazole, lansoprazole, clobazam), and CYP3A4 (e.g., midazolam, pimozide, simvastatin) is necessary when VYVANSE is co-administered [see Clinical Pharmacology (12.3) ] .
Lisdexamfetamine Also Interacts With
- Omeprazole minor
- Simvastatin minor
- Venlafaxine minor
- Atomoxetine minor
- Melatonin minor
Duloxetine Also Interacts With
- Aspirin moderate
- Fluoxetine minor
- Famotidine minor
- Buspirone minor
- Paroxetine minor
Frequently Asked Questions
What SPL severity band is on file for Lisdexamfetamine + Duloxetine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Duloxetine has 18 labeled pairs on file vs Lisdexamfetamine's 14. In the minor band specifically: Lisdexamfetamine has 14 (also Omeprazole, Simvastatin, Venlafaxine, Atomoxetine); Duloxetine has 17 (also Fluoxetine, Famotidine, Buspirone, Paroxetine).
What mechanism field is on file for Lisdexamfetamine and Duloxetine?
This ADHD medicine does not change how your body breaks down this antidepressant. They do not have a significant chemical interaction in the liver.
Duloxetine's labeled portfolio outnumbers Lisdexamfetamine
SPL source-record counts only. This page's band is minor · classes on file: Lisdexamfetamine (CNS Stimulant); Duloxetine (Serotonin-Norepinephrine Reuptake Inhibitor (SNRI)).
0 major · 0 moderate · 14 minor · 14 total
- Other minor peers for Lisdexamfetamine
- Omeprazole
- Simvastatin
- Venlafaxine
- Atomoxetine
0 major · 1 moderate · 17 minor · 18 total
- Other minor peers for Duloxetine
- Fluoxetine
- Famotidine
- Buspirone
- Paroxetine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.