Lisdexamfetamine and Duloxetine Interaction
Drug interaction information between Lisdexamfetamine and Duloxetine.
Lisdexamfetamine and Duloxetine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Lisdexamfetamine and Duloxetine. Major interactions are generally avoided, moderate ones may need monitoring or a dose adjustment, and minor ones are usually low-risk. This page shows the documented mechanism and guidance. Label-documented interactions are not a complete safety review, so always confirm your own medications with a pharmacist or doctor. Educational information, not medical advice.
How They Interact
This ADHD medicine does not change how your body breaks down this antidepressant. They do not have a significant chemical interaction in the liver.
What To Do
No dose adjustments are required for this combination. Continue taking your medications as scheduled.
FDA Label Information
From a pharmacokinetic perspective, no dose adjustment for drugs that are substrates of CYP1A2 (e.g., theophylline, duloxetine, melatonin), CYP2D6 (e.g., atomoxetine, desipramine, venlafaxine), CYP2C19 (e.g., omeprazole, lansoprazole, clobazam), and CYP3A4 (e.g., midazolam, pimozide, simvastatin) is necessary when VYVANSE is co-administered [see Clinical Pharmacology (12.3) ] .
Lisdexamfetamine Also Interacts With
- Omeprazole minor
- Simvastatin minor
- Venlafaxine minor
- Atomoxetine minor
- Melatonin minor
Duloxetine Also Interacts With
- Aspirin moderate
- Fluoxetine minor
- Famotidine minor
- Buspirone minor
- Paroxetine minor
Frequently Asked Questions
Can I take Lisdexamfetamine and Duloxetine together?
This is a minor interaction. No dose adjustments are required for this combination. Continue taking your medications as scheduled.
How serious is the interaction between Lisdexamfetamine and Duloxetine?
This interaction is classified as "minor" severity by the FDA. Minor interactions are unlikely to cause significant problems but should still be mentioned to your healthcare provider.
Why do Lisdexamfetamine and Duloxetine interact?
This ADHD medicine does not change how your body breaks down this antidepressant. They do not have a significant chemical interaction in the liver.
Understanding the Lisdexamfetamine and Duloxetine Interaction
FDA-approved prescribing information for these two drugs flags their combination as a minor-severity interaction. Lisdexamfetamine belongs to the CNS Stimulant class and Duloxetine belongs to the Serotonin-Norepinephrine Reuptake Inhibitor (SNRI) class - two categories that can collide when co-prescribed. The mechanism described in FDA labeling is: This ADHD medicine does not change how your body breaks down this antidepressant. Severity tiers matter: major flags generally advise avoidance, moderate flags often require monitoring or dose adjustment, and minor flags may only call for awareness.
Context around a specific patient determines real-world impact. Lisdexamfetamine has 14 total documented interactions on file in this dataset, and Duloxetine has 18. Each additional medication compounds the interaction surface, which is why pharmacists run full-profile checks rather than evaluating one pair at a time. FDA-derived guidance for this pair is: No dose adjustments are required for this combination. Timing of doses, renal and hepatic function, age, and other concurrent prescriptions all shape whether a labeled interaction matters clinically.
An interaction flag is not a verdict. A large share of labeled interactions are managed routinely in clinical practice, the fix may be as simple as spacing doses or adding a monitoring test. Others require the prescriber to choose a different medication entirely. This page surfaces FDA-sourced labeling and openFDA data for educational purposes only; it is not medical advice and cannot account for your full clinical picture. Never start, stop, or adjust either Lisdexamfetamine or Duloxetine based on a web page, speak with your prescriber or pharmacist before making any change.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. Always consult your healthcare provider about drug interactions.
Read our methodology - how this data is sourced, computed, and verified.