Simvastatin and Erythromycin Interaction
Drug interaction information between Simvastatin and Erythromycin.
Simvastatin and Erythromycin have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Simvastatin and Erythromycin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Erythromycin interferes with the way your body clears simvastatin, which can lead to a buildup of the medication in your blood.
FDA Label Information
Examples: Select azole anti-fungals (e.g., itraconazole, ketoconazole, posaconazole, and voriconazole), select macrolide antibiotics (e.g., erythromycin and clarithromycin, telithromycin), select HIV protease inhibitors (e.g., nelfinavir, ritonavir, and darunavir/ritonavir), select HCV protease inhibitors (e.g., boceprevir and telaprevir), cobicistat-containing products, and nefazodone.
Simvastatin Also Interacts With
- Diltiazem major
- Verapamil major
- Cyclosporine major
- Amiodarone major
- Dronedarone major
Erythromycin Also Interacts With
- Eplerenone major
- Pitavastatin major
- Risperidone major
- Sildenafil major
- Lefamulin moderate
Frequently Asked Questions
What SPL severity band is on file for Simvastatin + Erythromycin?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Erythromycin has 63 labeled pairs on file vs Simvastatin's 41. In the minor band specifically: Simvastatin has 21 (also Fenofibrate, Ketoconazole, Clarithromycin, Darunavir); Erythromycin has 53 (also Acetaminophen/Oxycodone, Alprazolam, Atorvastatin, Bromocriptine).
What mechanism field is on file for Simvastatin and Erythromycin?
Erythromycin interferes with the way your body clears simvastatin, which can lead to a buildup of the medication in your blood.
Simvastatin carries more major-labeled pairs than Erythromycin
SPL source-record counts only. This page's band is minor · classes on file: Simvastatin (HMG-CoA Reductase Inhibitor (Statin)); Erythromycin (Macrolide Antibiotic).
Simvastatin has 11 major-labeled pairs vs Erythromycin's 4. This page itself is in the minor band, not the major band.
11 major · 9 moderate · 21 minor · 41 total
- Other minor peers for Simvastatin
- Fenofibrate
- Ketoconazole
- Clarithromycin
- Darunavir
4 major · 6 moderate · 53 minor · 63 total
- Other minor peers for Erythromycin
- Acetaminophen/Oxycodone
- Alprazolam
- Atorvastatin
- Bromocriptine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.