Lisdexamfetamine and Omeprazole Interaction
Drug interaction information between Lisdexamfetamine and Omeprazole.
Lisdexamfetamine and Omeprazole have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Lisdexamfetamine and Omeprazole. Major interactions are generally avoided, moderate ones may need monitoring or a dose adjustment, and minor ones are usually low-risk. This page shows the documented mechanism and guidance. Label-documented interactions are not a complete safety review, so always confirm your own medications with a pharmacist or doctor. Educational information, not medical advice.
How They Interact
These two drugs do not significantly change how the body breaks each other down. They can be processed by the body at the same time without causing major problems.
What To Do
No dose changes are needed when taking these medicines together. You can continue taking them as prescribed.
FDA Label Information
7.2 Drugs Having No Clinically Important Interactions with Lisdexamfetamine Dimesylate Capsules From a pharmacokinetic perspective, no dose adjustment of lisdexamfetamine dimesylate capsules is necessary when lisdexamfetamine dimesylate capsules is co-administered with guanfacine, venlafaxine, or omeprazole. From a pharmacokinetic perspective, no dose adjustment for drugs that are substrates of CYP1A2 (e.g., theophylline, duloxetine, melatonin), CYP2D6 (e.g., atomoxetine, desipramine, venlafaxine), CYP2C19 (e.g., omeprazole, lansoprazole, clobazam), and CYP3A4 (e.g., midazolam, pimozide,...
Lisdexamfetamine Also Interacts With
- Simvastatin minor
- Duloxetine minor
- Venlafaxine minor
- Atomoxetine minor
- Melatonin minor
Omeprazole Also Interacts With
- Theophylline major
- Clarithromycin moderate
- Clopidogrel moderate
- Darunavir moderate
- Tacrolimus Topical moderate
Frequently Asked Questions
Can I take Lisdexamfetamine and Omeprazole together?
This is a minor interaction. No dose changes are needed when taking these medicines together. You can continue taking them as prescribed.
How serious is the interaction between Lisdexamfetamine and Omeprazole?
This interaction is classified as "minor" severity by the FDA. Minor interactions are unlikely to cause significant problems but should still be mentioned to your healthcare provider.
Why do Lisdexamfetamine and Omeprazole interact?
These two drugs do not significantly change how the body breaks each other down. They can be processed by the body at the same time without causing major problems.
Understanding the Lisdexamfetamine and Omeprazole Interaction
FDA-approved prescribing information for these two drugs flags their combination as a minor-severity interaction. Lisdexamfetamine belongs to the CNS Stimulant class and Omeprazole belongs to the Proton Pump Inhibitor (PPI) class - two categories that can collide when co-prescribed. The mechanism described in FDA labeling is: These two drugs do not significantly change how the body breaks each other down. Severity tiers matter: major flags generally advise avoidance, moderate flags often require monitoring or dose adjustment, and minor flags may only call for awareness.
Context around a specific patient determines real-world impact. Lisdexamfetamine has 14 total documented interactions on file in this dataset, and Omeprazole has 27. Each additional medication compounds the interaction surface, which is why pharmacists run full-profile checks rather than evaluating one pair at a time. FDA-derived guidance for this pair is: No dose changes are needed when taking these medicines together. Timing of doses, renal and hepatic function, age, and other concurrent prescriptions all shape whether a labeled interaction matters clinically.
An interaction flag is not a verdict. A large share of labeled interactions are managed routinely in clinical practice, the fix may be as simple as spacing doses or adding a monitoring test. Others require the prescriber to choose a different medication entirely. This page surfaces FDA-sourced labeling and openFDA data for educational purposes only; it is not medical advice and cannot account for your full clinical picture. Never start, stop, or adjust either Lisdexamfetamine or Omeprazole based on a web page, speak with your prescriber or pharmacist before making any change.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. Always consult your healthcare provider about drug interactions.
Read our methodology - how this data is sourced, computed, and verified.