Lisdexamfetamine and Omeprazole Interaction
Drug interaction information between Lisdexamfetamine and Omeprazole.
Lisdexamfetamine and Omeprazole have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Lisdexamfetamine and Omeprazole. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
These two drugs do not significantly change how the body breaks each other down. They can be processed by the body at the same time without causing major problems.
FDA Label Information
7.2 Drugs Having No Clinically Important Interactions with Lisdexamfetamine Dimesylate Capsules From a pharmacokinetic perspective, no dose adjustment of lisdexamfetamine dimesylate capsules is necessary when lisdexamfetamine dimesylate capsules is co-administered with guanfacine, venlafaxine, or omeprazole. From a pharmacokinetic perspective, no dose adjustment for drugs that are substrates of CYP1A2 (e.g., theophylline, duloxetine, melatonin), CYP2D6 (e.g., atomoxetine, desipramine, venlafaxine), CYP2C19 (e.g., omeprazole, lansoprazole, clobazam), and CYP3A4 (e.g., midazolam, pimozide,...
Lisdexamfetamine Also Interacts With
- Simvastatin minor
- Duloxetine minor
- Venlafaxine minor
- Atomoxetine minor
- Melatonin minor
Omeprazole Also Interacts With
- Theophylline major
- Clarithromycin moderate
- Clopidogrel moderate
- Darunavir moderate
- Tacrolimus Topical moderate
Frequently Asked Questions
What SPL severity band is on file for Lisdexamfetamine + Omeprazole?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Omeprazole has 27 labeled pairs on file vs Lisdexamfetamine's 14. In the minor band specifically: Lisdexamfetamine has 14 (also Simvastatin, Duloxetine, Venlafaxine, Atomoxetine); Omeprazole has 22 (also Aripiprazole, Atomoxetine, Brexpiprazole, Carbamazepine).
What mechanism field is on file for Lisdexamfetamine and Omeprazole?
These two drugs do not significantly change how the body breaks each other down. They can be processed by the body at the same time without causing major problems.
Omeprazole carries more major-labeled pairs than Lisdexamfetamine
SPL source-record counts only. This page's band is minor · classes on file: Lisdexamfetamine (CNS Stimulant); Omeprazole (Proton Pump Inhibitor (PPI)).
Omeprazole has 1 major-labeled pair vs Lisdexamfetamine's 0. This page itself is in the minor band, not the major band.
0 major · 0 moderate · 14 minor · 14 total
- Other minor peers for Lisdexamfetamine
- Simvastatin
- Duloxetine
- Venlafaxine
- Atomoxetine
1 major · 4 moderate · 22 minor · 27 total
- Other minor peers for Omeprazole
- Aripiprazole
- Atomoxetine
- Brexpiprazole
- Carbamazepine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.